Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes

Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes

Abstract Background Myelodysplastic syndrome (MDS) is a clonal disease of hematopoietic cells, characterized by hematopoietic cell hematopoiesis and a high risk of transformation into acute myeloid leukemia (AML). Although the underlying mechanism is unclear, MDS is often associated with immune syst...

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Bibliographic Details
Main Authors: Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang, Rong Fu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
Myelodysplastic syndrome
Immune system
Natural killer cells
Bone marrow mesenchymal stem cells
T cell immunoglobulin and ITIM domain
Online Access:https://doi.org/10.1186/s12964-022-00985-2

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