Homogeneous liquid–liquid microextraction coupled with HPLC/DAD for determination of nirmatrelvir and ritonavir as COVID-19 combination therapy in human plasma

Homogeneous liquid–liquid microextraction coupled with HPLC/DAD for determination of nirmatrelvir and ritonavir as COVID-19 combination therapy in human plasma

Abstract The study reports the development of a high-performance liquid chromatography/diode array detection method to measure the levels of nirmatrelvir and ritonavir in human plasma. These two antiviral medications are used for the treatment of COVID-19 and are marketed as Paxlovid®. The method em...

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Bibliographic Details
Main Authors: Inas A. Abdallah, Sherin F. Hammad, Alaa Bedair, Fotouh R. Mansour
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Chemistry
Subjects:
Nirmatrelvir
Ritonavir
COVID-19
HPLC
SARS-CoV-2, Sugaring-out
Online Access:https://doi.org/10.1186/s13065-023-01080-4

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