Comparative Investigation of R213G Mutation in DNA-Binding Domain of P53 Protein via Molecular Dynamics Simulation

Comparative Investigation of R213G Mutation in DNA-Binding Domain of P53 Protein via Molecular Dynamics Simulation

Introduction: P53 is a tumor suppressor protein with numerous missense mutations identified in its gene. These mutations are observed in a vast number of cancers. R213G is one of them which has a role in metastatic lung cancers. In this research, R213G was studied in comparison with the wild type vi...

Full description

Bibliographic Details
Main Authors: Elham Akbari, Mohammad Taghizadeh, Fahimeh Nemati
Format: Article
Language:fas
Published: Kerman University of Medical Sciences 2021-06-01
Series:مجله انفورماتیک سلامت و زیست پزشکی
Subjects:
root mean square fluctuation (rmsf)
protein flexibility
p53 protein
missense mutation
molecular dynamics simulation
Online Access:http://jhbmi.ir/article-1-524-en.html

Similar Items

Similar Items