Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain
To assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. Although single dosing of AS1892802 exerted a short-a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-01-01
|
| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319308898 |
| _version_ | 1818887988012122112 |
|---|---|
| author | Eiji Yoshimi Hiroko Yamamoto Yasuhisa Furuichi Yasuaki Shimizu Nobuaki Takeshita |
| author_facet | Eiji Yoshimi Hiroko Yamamoto Yasuhisa Furuichi Yasuaki Shimizu Nobuaki Takeshita |
| author_sort | Eiji Yoshimi |
| collection | DOAJ |
| description | To assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. Although single dosing of AS1892802 exerted a short-acting, moderate analgesic effect, repeated dosing exhibited a long-lasting and more potent analgesic effect in both models. Furthermore, the analgesic effect was sustained for seven days after the last administration. These results suggest that peripheral ROCK plays a crucial role in chronic pain maintenance and that AS1892802 may be useful in treating chronic pain. Keywords:: Rho kinase, monoiodoacetate-induced arthritis, streptozotocin-induced neuropathy |
| first_indexed | 2024-12-19T16:45:58Z |
| format | Article |
| id | doaj.art-448397a05b5349ecbde5e0025714cb4f |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-19T16:45:58Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-448397a05b5349ecbde5e0025714cb4f2022-12-21T20:13:39ZengElsevierJournal of Pharmacological Sciences1347-86132010-01-011141119122Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic PainEiji Yoshimi0Hiroko Yamamoto1Yasuhisa Furuichi2Yasuaki Shimizu3Nobuaki Takeshita4Pharmacology Research Laboratories, 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan; Corresponding author. eiji.yoshimi@jp.astellas.comPharmacology Research Laboratories, 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, JapanApplied Pharmacology Research Laboratories, Astellas Pharma, Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, JapanPharmacology Research Laboratories, 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, JapanPharmacology Research Laboratories, 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, JapanTo assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. Although single dosing of AS1892802 exerted a short-acting, moderate analgesic effect, repeated dosing exhibited a long-lasting and more potent analgesic effect in both models. Furthermore, the analgesic effect was sustained for seven days after the last administration. These results suggest that peripheral ROCK plays a crucial role in chronic pain maintenance and that AS1892802 may be useful in treating chronic pain. Keywords:: Rho kinase, monoiodoacetate-induced arthritis, streptozotocin-induced neuropathyhttp://www.sciencedirect.com/science/article/pii/S1347861319308898 |
| spellingShingle | Eiji Yoshimi Hiroko Yamamoto Yasuhisa Furuichi Yasuaki Shimizu Nobuaki Takeshita Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain Journal of Pharmacological Sciences |
| title | Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain |
| title_full | Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain |
| title_fullStr | Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain |
| title_full_unstemmed | Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain |
| title_short | Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain |
| title_sort | sustained analgesic effect of the rho kinase inhibitor as1892802 in rat models of chronic pain |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319308898 |
| work_keys_str_mv | AT eijiyoshimi sustainedanalgesiceffectoftherhokinaseinhibitoras1892802inratmodelsofchronicpain AT hirokoyamamoto sustainedanalgesiceffectoftherhokinaseinhibitoras1892802inratmodelsofchronicpain AT yasuhisafuruichi sustainedanalgesiceffectoftherhokinaseinhibitoras1892802inratmodelsofchronicpain AT yasuakishimizu sustainedanalgesiceffectoftherhokinaseinhibitoras1892802inratmodelsofchronicpain AT nobuakitakeshita sustainedanalgesiceffectoftherhokinaseinhibitoras1892802inratmodelsofchronicpain |