Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle
Conducting routine allergy tests of cattle with a simultaneous sample in TB-prone farms is necessary to confirm the stage of the epizootic process. The purpose of the research – to explore the pathomorphological changes in cows upon detection of para allergic reactions during diagnostic testing for...
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| Format: | Article |
| Language: | English |
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National University of Life and Environmental Sciences of Ukraine
2023-05-01
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| Series: | Ukrainian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://veterinaryscience.com.ua/en/journals/tom-14-2-2023/patomorfologichni-zmini-v-organakh-periferichnoyi-imunnoyi-sistemi-za-mikobakterioziv-velikoyi-rogatoyi-khudobi |
| _version_ | 1797268145436622848 |
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| author | Volodymyr Busol Petro Boiko Michał Bednarski Viktor Shevchuk Valery Mazur |
| author_facet | Volodymyr Busol Petro Boiko Michał Bednarski Viktor Shevchuk Valery Mazur |
| author_sort | Volodymyr Busol |
| collection | DOAJ |
| description | Conducting routine allergy tests of cattle with a simultaneous sample in TB-prone farms is necessary to confirm the stage of the epizootic process. The purpose of the research – to explore the pathomorphological changes in cows upon detection of para allergic reactions during diagnostic testing for tuberculosis. The diagnosis of tuberculosis in animals was performed comprehensively using all methods for tuberculosis control provided for in the guidelines – epidemiological, clinical, allergic, pathological, histomorphological, bacteriological and biological. It allowed establishing that the reactions to tuberculin in cows were of a paraallergic nature, caused by nontuberculous mycobacteria or so-called atypical mycobacteria. It was determined that cows that reacted positively to tuberculin and an atypical mycobacterial allergen and were sent for slaughter for diagnostic purposes did not demonstrate pathological changes characteristic of tuberculosis. However, pathological changes (granulomatous foci, atrophy of lymphoid and epithelioid tissue, hyperplasia of varying intensity and nature, dotted haemorrhages in the cortical zone) were observed in many lymph nodes, including mediastinal, mesenteric, pharyngeal and mandibular lymph nodes, indicating an active infectious process in the body of animals caused by nontuberculous mycobacteria. Therewith, several changes were observed in the lymph nodes during histomorphological examination: development of primary nodules of lymphocytes and reticular tissue in reactive centres, degradation and necrosis of lymphocytes, the establishment of cellular detritus in the centre of the nodules and capsules of epithelioid elements around the nodules, etc., which can be used to confirm the patterns of pathology development and, indirectly, the mechanism of sensitisation of the cow’s body, and therefore the nature of paraallergic reactions in animals. The obtained results are important for the timely detection and identification at the histomorphological level of a complex of changes in the organs and tissues of cows due to the penetration of nontuberculous mycobacteria, which is the key to the successful diagnosis of primary foci of mycobacteriosis and their effective prevention |
| first_indexed | 2024-04-25T01:27:49Z |
| format | Article |
| id | doaj.art-44840de9527548b78b8ec1d57f9f8b75 |
| institution | Directory Open Access Journal |
| issn | 2663-967X 2663-9688 |
| language | English |
| last_indexed | 2024-04-25T01:27:49Z |
| publishDate | 2023-05-01 |
| publisher | National University of Life and Environmental Sciences of Ukraine |
| record_format | Article |
| series | Ukrainian Journal of Veterinary Sciences |
| spelling | doaj.art-44840de9527548b78b8ec1d57f9f8b752024-03-08T14:45:15ZengNational University of Life and Environmental Sciences of UkraineUkrainian Journal of Veterinary Sciences2663-967X2663-96882023-05-0114292710.31548/veterinary2.2023.09Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattleVolodymyr Busol0https://orcid.org/0000-0002-9618-0493Petro Boiko1https://orcid.org/0000-0003-1418-1159Michał Bednarski2https://orcid.org/0000-0003-0292-7929Viktor Shevchuk3https://orcid.org/0000-0002-5937-3333Valery Mazur4https://orcid.org/0000-0002-1311-9882National scientific center “Institute of Experimental and Clinical Veterinary Medicine”Lesya Ukrainka Volyn National UniversityWroclaw University of Environmental and Life SciencesNational University of Life and Environmental Sciences of UkraineNational University of Life and Environmental Sciences of UkraineConducting routine allergy tests of cattle with a simultaneous sample in TB-prone farms is necessary to confirm the stage of the epizootic process. The purpose of the research – to explore the pathomorphological changes in cows upon detection of para allergic reactions during diagnostic testing for tuberculosis. The diagnosis of tuberculosis in animals was performed comprehensively using all methods for tuberculosis control provided for in the guidelines – epidemiological, clinical, allergic, pathological, histomorphological, bacteriological and biological. It allowed establishing that the reactions to tuberculin in cows were of a paraallergic nature, caused by nontuberculous mycobacteria or so-called atypical mycobacteria. It was determined that cows that reacted positively to tuberculin and an atypical mycobacterial allergen and were sent for slaughter for diagnostic purposes did not demonstrate pathological changes characteristic of tuberculosis. However, pathological changes (granulomatous foci, atrophy of lymphoid and epithelioid tissue, hyperplasia of varying intensity and nature, dotted haemorrhages in the cortical zone) were observed in many lymph nodes, including mediastinal, mesenteric, pharyngeal and mandibular lymph nodes, indicating an active infectious process in the body of animals caused by nontuberculous mycobacteria. Therewith, several changes were observed in the lymph nodes during histomorphological examination: development of primary nodules of lymphocytes and reticular tissue in reactive centres, degradation and necrosis of lymphocytes, the establishment of cellular detritus in the centre of the nodules and capsules of epithelioid elements around the nodules, etc., which can be used to confirm the patterns of pathology development and, indirectly, the mechanism of sensitisation of the cow’s body, and therefore the nature of paraallergic reactions in animals. The obtained results are important for the timely detection and identification at the histomorphological level of a complex of changes in the organs and tissues of cows due to the penetration of nontuberculous mycobacteria, which is the key to the successful diagnosis of primary foci of mycobacteriosis and their effective preventionhttps://veterinaryscience.com.ua/en/journals/tom-14-2-2023/patomorfologichni-zmini-v-organakh-periferichnoyi-imunnoyi-sistemi-za-mikobakterioziv-velikoyi-rogatoyi-khudobituberculosistuberculinantigen of atypical mycobacteriainfectious processatypical mycobacteriaallergic reactionsdiagnostics |
| spellingShingle | Volodymyr Busol Petro Boiko Michał Bednarski Viktor Shevchuk Valery Mazur Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle Ukrainian Journal of Veterinary Sciences tuberculosis tuberculin antigen of atypical mycobacteria infectious process atypical mycobacteria allergic reactions diagnostics |
| title | Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| title_full | Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| title_fullStr | Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| title_full_unstemmed | Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| title_short | Pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| title_sort | pathomorphological changes in the organs of the peripheral immune system in mycobacteriosis of cattle |
| topic | tuberculosis tuberculin antigen of atypical mycobacteria infectious process atypical mycobacteria allergic reactions diagnostics |
| url | https://veterinaryscience.com.ua/en/journals/tom-14-2-2023/patomorfologichni-zmini-v-organakh-periferichnoyi-imunnoyi-sistemi-za-mikobakterioziv-velikoyi-rogatoyi-khudobi |
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