Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan
Abstract Background Spread of vancomycin-resistant Enterococcus (VRE) is a global concern as a significant cause of healthcare-associated infections. A series of VRE faecium (VREf) outbreaks caused by clonal propagation due to interhospital transmission occurred in six general hospitals in Aomori pr...
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| Format: | Article |
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BMC
2022-07-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-022-01136-5 |
| _version_ | 1817968639585812480 |
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| author | Norihiro Saito Junichi Kitazawa Hiroko Horiuchi Takeo Yamamoto Masahiko Kimura Fumio Inoue Mika Matsui Satoko Minakawa Masamichi Itoga Junichiro Tsuchiya Satowa Suzuki Junzo Hisatsune Yoshiaki Gu Motoyuki Sugai Hiroyuki Kayaba |
| author_facet | Norihiro Saito Junichi Kitazawa Hiroko Horiuchi Takeo Yamamoto Masahiko Kimura Fumio Inoue Mika Matsui Satoko Minakawa Masamichi Itoga Junichiro Tsuchiya Satowa Suzuki Junzo Hisatsune Yoshiaki Gu Motoyuki Sugai Hiroyuki Kayaba |
| author_sort | Norihiro Saito |
| collection | DOAJ |
| description | Abstract Background Spread of vancomycin-resistant Enterococcus (VRE) is a global concern as a significant cause of healthcare-associated infections. A series of VRE faecium (VREf) outbreaks caused by clonal propagation due to interhospital transmission occurred in six general hospitals in Aomori prefecture, Japan. Methods The number of patients with VREf was obtained from thirty seven hospitals participating in the local network of Aomori prefecture. Thirteen hospitals performed active screening tests for VRE. Whole genome sequencing analysis was performed. Results The total number of cases with VREf amounted to 500 in fourteen hospitals in Aomori from Jan 2018 to April 2021. It took more than three years for the frequency of detection of VRE to return to pre-outbreak levels. The duration and size of outbreaks differed between hospitals according to the countermeasures available at each hospital. Whole genome sequencing analysis indicated vanA-type VREf ST1421 for most samples from six hospitals. Conclusions This was the first multi-jurisdictional outbreak of VREf sequence type 1421 in Japan. In addition to strict infection control measures, continuous monitoring of VRE detection in local medical regions and smooth and immediate communication among hospitals are required to prevent VREf outbreaks. |
| first_indexed | 2024-04-13T20:11:47Z |
| format | Article |
| id | doaj.art-44853222e16d4a408d3f42ed2b9734f4 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-13T20:11:47Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-44853222e16d4a408d3f42ed2b9734f42022-12-22T02:31:50ZengBMCAntimicrobial Resistance and Infection Control2047-29942022-07-0111111210.1186/s13756-022-01136-5Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, JapanNorihiro Saito0Junichi Kitazawa1Hiroko Horiuchi2Takeo Yamamoto3Masahiko Kimura4Fumio Inoue5Mika Matsui6Satoko Minakawa7Masamichi Itoga8Junichiro Tsuchiya9Satowa Suzuki10Junzo Hisatsune11Yoshiaki Gu12Motoyuki Sugai13Hiroyuki Kayaba14Department of Clinical Laboratory Medicine, Hirosaki University Graduate School of MedicineAomori Infection Control NetworkAomori Infection Control NetworkAomori Infection Control NetworkClinical Laboratory, Hirosaki University HospitalClinical Laboratory, Hirosaki University HospitalAomori Infection Control NetworkClinical Laboratory, Hirosaki University HospitalClinical Laboratory, Hirosaki University HospitalClinical Laboratory, Hirosaki University HospitalAntimicrobial Resistance Research Center, National Institute of Infectious DiseasesAntimicrobial Resistance Research Center, National Institute of Infectious DiseasesAMR Clinical Reference Center, National Center for Global Health and MedicineAntimicrobial Resistance Research Center, National Institute of Infectious DiseasesDepartment of Clinical Laboratory Medicine, Hirosaki University Graduate School of MedicineAbstract Background Spread of vancomycin-resistant Enterococcus (VRE) is a global concern as a significant cause of healthcare-associated infections. A series of VRE faecium (VREf) outbreaks caused by clonal propagation due to interhospital transmission occurred in six general hospitals in Aomori prefecture, Japan. Methods The number of patients with VREf was obtained from thirty seven hospitals participating in the local network of Aomori prefecture. Thirteen hospitals performed active screening tests for VRE. Whole genome sequencing analysis was performed. Results The total number of cases with VREf amounted to 500 in fourteen hospitals in Aomori from Jan 2018 to April 2021. It took more than three years for the frequency of detection of VRE to return to pre-outbreak levels. The duration and size of outbreaks differed between hospitals according to the countermeasures available at each hospital. Whole genome sequencing analysis indicated vanA-type VREf ST1421 for most samples from six hospitals. Conclusions This was the first multi-jurisdictional outbreak of VREf sequence type 1421 in Japan. In addition to strict infection control measures, continuous monitoring of VRE detection in local medical regions and smooth and immediate communication among hospitals are required to prevent VREf outbreaks.https://doi.org/10.1186/s13756-022-01136-5Vancomycin-resistant Enterococcus (VRE)OutbreakInterhospital transmissionInfection control |
| spellingShingle | Norihiro Saito Junichi Kitazawa Hiroko Horiuchi Takeo Yamamoto Masahiko Kimura Fumio Inoue Mika Matsui Satoko Minakawa Masamichi Itoga Junichiro Tsuchiya Satowa Suzuki Junzo Hisatsune Yoshiaki Gu Motoyuki Sugai Hiroyuki Kayaba Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan Antimicrobial Resistance and Infection Control Vancomycin-resistant Enterococcus (VRE) Outbreak Interhospital transmission Infection control |
| title | Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan |
| title_full | Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan |
| title_fullStr | Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan |
| title_full_unstemmed | Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan |
| title_short | Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan |
| title_sort | interhospital transmission of vancomycin resistant enterococcus faecium in aomori japan |
| topic | Vancomycin-resistant Enterococcus (VRE) Outbreak Interhospital transmission Infection control |
| url | https://doi.org/10.1186/s13756-022-01136-5 |
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