SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report
Abstract Lambert–Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX‐1 antibodies are support for the diagnosis of LEMS and have high specificity...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13740 |
| _version_ | 1797244473934086144 |
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| author | Liming Zhao Hongyan He Weixin Han Yizhe Meng Lifei Kang Yanqiang Chen |
| author_facet | Liming Zhao Hongyan He Weixin Han Yizhe Meng Lifei Kang Yanqiang Chen |
| author_sort | Liming Zhao |
| collection | DOAJ |
| description | Abstract Lambert–Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX‐1 antibodies are support for the diagnosis of LEMS and have high specificity for small cell lung cancer (SCLC). In this paper, we report a case of a 56‐year‐old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropositive SOX‐1 antibodies. Primary screening with chest computed tomography (CT) and integrated PET/CT did not reveal any tumor. After continuous follow‐up, SCLC was found by chest CT and confirmed with pathological examination 10 months after the diagnosis of LEMS. Long‐term follow‐up and screening for occult SCLC in LEMS patients with positive SOX‐1 antibodies are very important. |
| first_indexed | 2024-04-24T19:11:35Z |
| format | Article |
| id | doaj.art-4485c61bbcda4afca8531fd7fc3b38c6 |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-04-24T19:11:35Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-4485c61bbcda4afca8531fd7fc3b38c62024-03-26T09:34:37ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2024-03-01183n/an/a10.1111/crj.13740SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case reportLiming Zhao0Hongyan He1Weixin Han2Yizhe Meng3Lifei Kang4Yanqiang Chen5Department of Neurology Hebei Chest Hospital Shijiazhuang Hebei ChinaDepartment of Neurology Hebei Chest Hospital Shijiazhuang Hebei ChinaDepartment of Neurology Hebei Chest Hospital Shijiazhuang Hebei ChinaDepartment of Neurology Hebei Chest Hospital Shijiazhuang Hebei ChinaDepartment of Pathology Hebei Chest Hospital Shijiazhuang Hebei ChinaDepartment of Neurology Hebei Chest Hospital Shijiazhuang Hebei ChinaAbstract Lambert–Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX‐1 antibodies are support for the diagnosis of LEMS and have high specificity for small cell lung cancer (SCLC). In this paper, we report a case of a 56‐year‐old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropositive SOX‐1 antibodies. Primary screening with chest computed tomography (CT) and integrated PET/CT did not reveal any tumor. After continuous follow‐up, SCLC was found by chest CT and confirmed with pathological examination 10 months after the diagnosis of LEMS. Long‐term follow‐up and screening for occult SCLC in LEMS patients with positive SOX‐1 antibodies are very important.https://doi.org/10.1111/crj.13740Lambert–Eaton myasthenic syndromeoccult cancersmall cell lung cancerSOX‐1 antibody |
| spellingShingle | Liming Zhao Hongyan He Weixin Han Yizhe Meng Lifei Kang Yanqiang Chen SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report The Clinical Respiratory Journal Lambert–Eaton myasthenic syndrome occult cancer small cell lung cancer SOX‐1 antibody |
| title | SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report |
| title_full | SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report |
| title_fullStr | SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report |
| title_full_unstemmed | SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report |
| title_short | SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report |
| title_sort | sox 1 antibodies positive lambert eaton myasthenic syndrome with occult small cell lung cancer a case report |
| topic | Lambert–Eaton myasthenic syndrome occult cancer small cell lung cancer SOX‐1 antibody |
| url | https://doi.org/10.1111/crj.13740 |
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