Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children
While non-operative treatment has emerged as an alternative to surgery for the treatment of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these in a feasibility randomised trial. Of 57 randomised participants, data were av...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-12-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/7/1/e001673.full |
| _version_ | 1797367952309223424 |
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| author | Maria Chorozoglou Lucy Beasant Esther Crawley Isabel Reading Simon Eaton Natalie Hutchings Nigel J Hall Bridget Young Jane Blazeby Erin Walker Dean Rex Harriet Corbett Michael Stanton Frances C Sherratt Elizabeth Dixon |
| author_facet | Maria Chorozoglou Lucy Beasant Esther Crawley Isabel Reading Simon Eaton Natalie Hutchings Nigel J Hall Bridget Young Jane Blazeby Erin Walker Dean Rex Harriet Corbett Michael Stanton Frances C Sherratt Elizabeth Dixon |
| author_sort | Maria Chorozoglou |
| collection | DOAJ |
| description | While non-operative treatment has emerged as an alternative to surgery for the treatment of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these in a feasibility randomised trial. Of 57 randomised participants, data were available for 26. Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorter duration of requiring analgesia, more rapid return to normal activities and shorter parental absence from work. These preliminary data suggest differences exist in recovery profile and quality of life between these treatments that are important to measure in a larger RCT. Trial registration number is ISRCTN15830435. |
| first_indexed | 2024-03-08T17:25:30Z |
| format | Article |
| id | doaj.art-44891ee8788d4ae9a0ecd5f02bc4a3ff |
| institution | Directory Open Access Journal |
| issn | 2399-9772 |
| language | English |
| last_indexed | 2024-03-08T17:25:30Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj.art-44891ee8788d4ae9a0ecd5f02bc4a3ff2024-01-02T20:55:07ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722023-12-017110.1136/bmjpo-2022-001673Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in childrenMaria Chorozoglou0Lucy Beasant1Esther Crawley2Isabel Reading3Simon Eaton4Natalie Hutchings5Nigel J Hall6Bridget Young7Jane Blazeby8Erin Walker9Dean Rex10Harriet Corbett11Michael Stanton12Frances C Sherratt13Elizabeth Dixon14Southampton Health Technology Assessment Centre, University of Southampton Faculty of Medicine, Southampton, UKCentre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UKCentre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UKPrimary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UKUCL Great Ormond Street Institute of Child Health, London, UKSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UKDepartment of Paediatric Surgery and Urology, Southampton Children`s Hospital, Southampton, UKDepartment of Public Health, Policy and Systems, University of Liverpool, Liverpool, UKBristol Centre for Surgical Research and Bristol Biomedical Research Centre, University of Bristol Medical School, Bristol, UKGreat Ormond Street Hospital For Children NHS Trust, London, UKPaediatric Surgery, St George`s University Hospitals NHS Foundation Trust, London, UK2Alder Hey Children’s HospitalDepartment of Paediatric Surgery and Urology, Southampton Children`s Hospital, Southampton, UKDepartment of Public Health, Policy and Systems, University of Liverpool, Liverpool, UKSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UKWhile non-operative treatment has emerged as an alternative to surgery for the treatment of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these in a feasibility randomised trial. Of 57 randomised participants, data were available for 26. Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorter duration of requiring analgesia, more rapid return to normal activities and shorter parental absence from work. These preliminary data suggest differences exist in recovery profile and quality of life between these treatments that are important to measure in a larger RCT. Trial registration number is ISRCTN15830435.https://bmjpaedsopen.bmj.com/content/7/1/e001673.full |
| spellingShingle | Maria Chorozoglou Lucy Beasant Esther Crawley Isabel Reading Simon Eaton Natalie Hutchings Nigel J Hall Bridget Young Jane Blazeby Erin Walker Dean Rex Harriet Corbett Michael Stanton Frances C Sherratt Elizabeth Dixon Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children BMJ Paediatrics Open |
| title | Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| title_full | Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| title_fullStr | Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| title_full_unstemmed | Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| title_short | Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| title_sort | patient centred outcomes following non operative treatment or appendicectomy for uncomplicated acute appendicitis in children |
| url | https://bmjpaedsopen.bmj.com/content/7/1/e001673.full |
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