Involvement of PKMζ in Stress Response and Depression
The stress system in the brain plays a pivotal role in keeping humans and animals from harmful stimuli. However, excessive stress will cause maladaptive changes to the stress system and lead to depression. Despite the high prevalence of depression, the treatment remains limited. PKMζ, an atypical PK...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.907767/full |
| _version_ | 1818215608431411200 |
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| author | Jianfeng Liu |
| author_facet | Jianfeng Liu |
| author_sort | Jianfeng Liu |
| collection | DOAJ |
| description | The stress system in the brain plays a pivotal role in keeping humans and animals from harmful stimuli. However, excessive stress will cause maladaptive changes to the stress system and lead to depression. Despite the high prevalence of depression, the treatment remains limited. PKMζ, an atypical PKC isoform, has been demonstrated to play a crucial role in maintaining long-term potentiation and memory. Recent evidence shows that PKMζ is also involved in stress response and depressive-like behavior. In particular, it was demonstrated that stress that resulted in depressive-like behavior could decrease the expression of PKMζ in the prefrontal cortex, which could be reversed by antidepressants. Importantly, modulation of PKMζ expression could regulate depressive-like behaviors and the actions of antidepressants. These data suggested that PKMζ could be a molecular target for developing novel antidepressants. Here, I review the advance on the role of PKMζ in mediating stress response and its involvement in the development of depression. |
| first_indexed | 2024-12-12T06:38:47Z |
| format | Article |
| id | doaj.art-448e0bd5cbe44f6a8d25371eb0b81473 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T06:38:47Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-448e0bd5cbe44f6a8d25371eb0b814732022-12-22T00:34:25ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-05-011610.3389/fncel.2022.907767907767Involvement of PKMζ in Stress Response and DepressionJianfeng LiuThe stress system in the brain plays a pivotal role in keeping humans and animals from harmful stimuli. However, excessive stress will cause maladaptive changes to the stress system and lead to depression. Despite the high prevalence of depression, the treatment remains limited. PKMζ, an atypical PKC isoform, has been demonstrated to play a crucial role in maintaining long-term potentiation and memory. Recent evidence shows that PKMζ is also involved in stress response and depressive-like behavior. In particular, it was demonstrated that stress that resulted in depressive-like behavior could decrease the expression of PKMζ in the prefrontal cortex, which could be reversed by antidepressants. Importantly, modulation of PKMζ expression could regulate depressive-like behaviors and the actions of antidepressants. These data suggested that PKMζ could be a molecular target for developing novel antidepressants. Here, I review the advance on the role of PKMζ in mediating stress response and its involvement in the development of depression.https://www.frontiersin.org/articles/10.3389/fncel.2022.907767/fulldepressionstressPKMζmemoryantidepressants |
| spellingShingle | Jianfeng Liu Involvement of PKMζ in Stress Response and Depression Frontiers in Cellular Neuroscience depression stress PKMζ memory antidepressants |
| title | Involvement of PKMζ in Stress Response and Depression |
| title_full | Involvement of PKMζ in Stress Response and Depression |
| title_fullStr | Involvement of PKMζ in Stress Response and Depression |
| title_full_unstemmed | Involvement of PKMζ in Stress Response and Depression |
| title_short | Involvement of PKMζ in Stress Response and Depression |
| title_sort | involvement of pkmζ in stress response and depression |
| topic | depression stress PKMζ memory antidepressants |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.907767/full |
| work_keys_str_mv | AT jianfengliu involvementofpkmzinstressresponseanddepression |