Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria
Objective: Polypharmacy prevalence is increasing worldwide, and it is becoming more popular among the elderly. This study aimed to compare the prevalence of potentially inappropriate medications (PIMs) using the Beers criteria (2019 edition), criteria for potentially inappropriate medications for ol...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1265463/full |
| _version_ | 1797367742067638272 |
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| author | Xiaojuan Zhu Feng Zhang Yong Zhao Wen Zhang Yahui Zhang Jianchun Wang |
| author_facet | Xiaojuan Zhu Feng Zhang Yong Zhao Wen Zhang Yahui Zhang Jianchun Wang |
| author_sort | Xiaojuan Zhu |
| collection | DOAJ |
| description | Objective: Polypharmacy prevalence is increasing worldwide, and it is becoming more popular among the elderly. This study aimed to compare the prevalence of potentially inappropriate medications (PIMs) using the Beers criteria (2019 edition), criteria for potentially inappropriate medications for older adults in China (Chinese criteria), Screening Tool of Older Persons’ Prescriptions (STOPP), and Screening Tool to Alert to Right Treatment (START) criteria and to identify risk factors associated with PIM use.Methods: This was a cross-sectional study with a sample of 276 inpatients aged ≥65 years old from January 2020 to June 2020. A cross-sectional study was conducted to analyze PIMs based on the Beers (2019 edition), Chinese, STOPP, and START criteria. PIMs use was analysed based on four different criteria and logistic regression analysis was used to investigate independent factors associated with PIM use.Results: The mean number of medications used by the elderly population was nine (range, 0–28). A total of 252 patients (accounting for 91.30%) took five or more medications and 120 patients (accounting for 43.48%) took 10 or more medications. The prevalence rates of PIMs were 66.30% (183/276), 55.07% (152/276), 26.45% (73/276), and 64.13% (177/276) determined by the Beers, Chinese, STOPP, and START criteria, respectively. The top PIMs screened using the Beers, Chinese, and STOPP criteria were proton pump inhibitors, clopidogrel, and benzodiazepines, respectively. Missed use of ACEI in patients with systolic heart failure and/or coronary artery disease was found to be the most common potential prescription omission (PPOs) analyzed using the START criteria. Logistic regression analysis showed that the strongest predictor of PIMs, as determined by all four criteria, was an increased number of medications (p < 0.001). Age was another risk factor for PIMs based on the STOPP criteria in our study (p < 0.05).Conclusion: Polypharmacy and PIMs were common in our study, and the risk of PIMs correlated with polypharmacy. Application of the Beers, Chinese, STOPP, and START criteria is a useful tool for detecting PIM use. |
| first_indexed | 2024-03-08T17:21:38Z |
| format | Article |
| id | doaj.art-448f106970dc42a7884789454647bf5a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T17:21:38Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-448f106970dc42a7884789454647bf5a2024-01-03T04:33:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011410.3389/fphar.2023.12654631265463Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteriaXiaojuan Zhu0Feng Zhang1Yong Zhao2Wen Zhang3Yahui Zhang4Jianchun Wang5Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Clinical Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Clinical Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaObjective: Polypharmacy prevalence is increasing worldwide, and it is becoming more popular among the elderly. This study aimed to compare the prevalence of potentially inappropriate medications (PIMs) using the Beers criteria (2019 edition), criteria for potentially inappropriate medications for older adults in China (Chinese criteria), Screening Tool of Older Persons’ Prescriptions (STOPP), and Screening Tool to Alert to Right Treatment (START) criteria and to identify risk factors associated with PIM use.Methods: This was a cross-sectional study with a sample of 276 inpatients aged ≥65 years old from January 2020 to June 2020. A cross-sectional study was conducted to analyze PIMs based on the Beers (2019 edition), Chinese, STOPP, and START criteria. PIMs use was analysed based on four different criteria and logistic regression analysis was used to investigate independent factors associated with PIM use.Results: The mean number of medications used by the elderly population was nine (range, 0–28). A total of 252 patients (accounting for 91.30%) took five or more medications and 120 patients (accounting for 43.48%) took 10 or more medications. The prevalence rates of PIMs were 66.30% (183/276), 55.07% (152/276), 26.45% (73/276), and 64.13% (177/276) determined by the Beers, Chinese, STOPP, and START criteria, respectively. The top PIMs screened using the Beers, Chinese, and STOPP criteria were proton pump inhibitors, clopidogrel, and benzodiazepines, respectively. Missed use of ACEI in patients with systolic heart failure and/or coronary artery disease was found to be the most common potential prescription omission (PPOs) analyzed using the START criteria. Logistic regression analysis showed that the strongest predictor of PIMs, as determined by all four criteria, was an increased number of medications (p < 0.001). Age was another risk factor for PIMs based on the STOPP criteria in our study (p < 0.05).Conclusion: Polypharmacy and PIMs were common in our study, and the risk of PIMs correlated with polypharmacy. Application of the Beers, Chinese, STOPP, and START criteria is a useful tool for detecting PIM use.https://www.frontiersin.org/articles/10.3389/fphar.2023.1265463/fullpotentially inappropriate medicationsbeers criteriaChinese criteriaelderlySTOPP START criteria |
| spellingShingle | Xiaojuan Zhu Feng Zhang Yong Zhao Wen Zhang Yahui Zhang Jianchun Wang Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria Frontiers in Pharmacology potentially inappropriate medications beers criteria Chinese criteria elderly STOPP START criteria |
| title | Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria |
| title_full | Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria |
| title_fullStr | Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria |
| title_full_unstemmed | Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria |
| title_short | Evaluation of potentially inappropriate medications for the elderly according to beers, STOPP, START, and Chinese criteria |
| title_sort | evaluation of potentially inappropriate medications for the elderly according to beers stopp start and chinese criteria |
| topic | potentially inappropriate medications beers criteria Chinese criteria elderly STOPP START criteria |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1265463/full |
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