Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study
Among phytochemical and pharmaceutical investigations, the green production of silver nanoparticles has emerged as the crown jewel of this investigation. The production of acridinedione substances is greatly aided by the high catalytic activity of these nanoparticles. Structures and morphologies wer...
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| Format: | Article |
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Elsevier
2024-06-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022424000276 |
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| author | Perumal Gobinath Ponnusamy Packialakshmi Govindasamy Thilagavathi Natarajan Elangovan Renjith Thomas Radhakrishnan Surendrakumar |
| author_facet | Perumal Gobinath Ponnusamy Packialakshmi Govindasamy Thilagavathi Natarajan Elangovan Renjith Thomas Radhakrishnan Surendrakumar |
| author_sort | Perumal Gobinath |
| collection | DOAJ |
| description | Among phytochemical and pharmaceutical investigations, the green production of silver nanoparticles has emerged as the crown jewel of this investigation. The production of acridinedione substances is greatly aided by the high catalytic activity of these nanoparticles. Structures and morphologies were determined by using a wide range of analytical techniques, including nuclear magnetic resonance (1H &13C), Fourier transform infrared spectroscopy, mass spectrometry, elemental investigation, scanning electron microscopy, also transmission electron microscopy. Acridinedione compounds' cytotoxicity was measured using the MTT assay with doxorubicin as the reference drug in a number of cancerous and healthy cell lines, comprising Human embryonic kidney cell (HEK293), liver cell (LO2), and lung cell (MRC5). The cytotoxicity compound 1h was shown to be especially active (HepG2, LC50-0.5 µM; MCF-7, LC50-0.64 µM; HeLa, LC50-0.52 µM). By eliciting IC50 values larger than 100 µg/M in normal cell lines (HEK-293), (LO2), and (MRC5), the synthesised compounds proved to be safe. In addition, we present the results from an in-silico analysis of the Methoxsalen protein (1Z11). The binding affinity of compound 1h for the 1Z11 protein is greater than that of other compounds (-11.7 kcal/mol), but it is less than that of Doxorubicin (-10.2 kcal/mol). Hence, the chemical 1h may be used to create powerful cancer drugs. |
| first_indexed | 2024-03-08T12:08:32Z |
| format | Article |
| id | doaj.art-448f19e21ed64766bd57bac77e2972be |
| institution | Directory Open Access Journal |
| issn | 2667-0224 |
| language | English |
| last_indexed | 2024-03-08T12:08:32Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj.art-448f19e21ed64766bd57bac77e2972be2024-01-23T04:16:35ZengElsevierChemical Physics Impact2667-02242024-06-018100483Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking studyPerumal Gobinath0Ponnusamy Packialakshmi1Govindasamy Thilagavathi2Natarajan Elangovan3Renjith Thomas4Radhakrishnan Surendrakumar5Research Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanamapatti, Tamilnadu, IndiaResearch Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanamapatti, Tamilnadu, IndiaPG & Research Department of Physics, Nehru Memorial College (Affiliated Bharathidasan University), Puthanamapatti, Tamilnadu, IndiaCentre for Theoretical and Computational Chemistry, St Berchmans College (Autonomous), Mahatma Gandhi University, Changanassery, Kerala, 686101, IndiaDepartment of Mechanical Engineering, University Centre for Research & Development Chandigarh University, Gharuan, Mohali, Punjab, India; Corresponding authors.Research Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanamapatti, Tamilnadu, India; Corresponding authors.Among phytochemical and pharmaceutical investigations, the green production of silver nanoparticles has emerged as the crown jewel of this investigation. The production of acridinedione substances is greatly aided by the high catalytic activity of these nanoparticles. Structures and morphologies were determined by using a wide range of analytical techniques, including nuclear magnetic resonance (1H &13C), Fourier transform infrared spectroscopy, mass spectrometry, elemental investigation, scanning electron microscopy, also transmission electron microscopy. Acridinedione compounds' cytotoxicity was measured using the MTT assay with doxorubicin as the reference drug in a number of cancerous and healthy cell lines, comprising Human embryonic kidney cell (HEK293), liver cell (LO2), and lung cell (MRC5). The cytotoxicity compound 1h was shown to be especially active (HepG2, LC50-0.5 µM; MCF-7, LC50-0.64 µM; HeLa, LC50-0.52 µM). By eliciting IC50 values larger than 100 µg/M in normal cell lines (HEK-293), (LO2), and (MRC5), the synthesised compounds proved to be safe. In addition, we present the results from an in-silico analysis of the Methoxsalen protein (1Z11). The binding affinity of compound 1h for the 1Z11 protein is greater than that of other compounds (-11.7 kcal/mol), but it is less than that of Doxorubicin (-10.2 kcal/mol). Hence, the chemical 1h may be used to create powerful cancer drugs.http://www.sciencedirect.com/science/article/pii/S2667022424000276Silver nanoparticlesVitex negundo extractAcridinedione analoguesCytotoxicityMolecular docking |
| spellingShingle | Perumal Gobinath Ponnusamy Packialakshmi Govindasamy Thilagavathi Natarajan Elangovan Renjith Thomas Radhakrishnan Surendrakumar Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study Chemical Physics Impact Silver nanoparticles Vitex negundo extract Acridinedione analogues Cytotoxicity Molecular docking |
| title | Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study |
| title_full | Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study |
| title_fullStr | Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study |
| title_full_unstemmed | Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study |
| title_short | Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study |
| title_sort | design synthesis of new 4 5 dibenzylidene 9 10 diphenyl 1 2 7 8 9 10 hexahydroacridine 3 6 dione derivatives using extract of vitexnegundo cytotoxic activity amp molecular docking study |
| topic | Silver nanoparticles Vitex negundo extract Acridinedione analogues Cytotoxicity Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2667022424000276 |
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