Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex
The dorsal and ventral parts of the lateral prefrontal cortex have been thought to play distinct roles in decision making. Although its dorsal part such as the frontal eye field (FEF) is shown to play roles in accumulation of sensory information during perceptual decision making, the role of the ven...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00365/full |
| _version_ | 1831757284975312896 |
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| author | Rei eAkaishi Rei eAkaishi Naoko eUeda Katsuyuki eSakai |
| author_facet | Rei eAkaishi Rei eAkaishi Naoko eUeda Katsuyuki eSakai |
| author_sort | Rei eAkaishi |
| collection | DOAJ |
| description | The dorsal and ventral parts of the lateral prefrontal cortex have been thought to play distinct roles in decision making. Although its dorsal part such as the frontal eye field (FEF) is shown to play roles in accumulation of sensory information during perceptual decision making, the role of the ventral prefrontal cortex (PFv) is not well-documented. Previous studies have suggested that the PFv is involved in selective attention to the task-relevant information and is associated with accuracy of the behavioral performance. It is unknown, however, whether the accumulation and selection processes are anatomically dissociated between the FEF and PFv. Here we show that, by using concurrent TMS and EEG recording, the short-latency (20 – 40 ms) TMS-evoked potentials after stimulation of the FEF change as a function of the time to behavioral response, whereas those after stimulation of the PFv change depending on whether the response is correct or not. The potentials after stimulation of either region did not show significant interaction between time to response and performance accuracy, suggesting dissociation between the processes subserved by the FEF and PFv networks. The results are consistent with the idea that the network involving the FEF plays a role in information accumulation, whereas the network involving the PFv plays a role in selecting task relevant information. In addition, stimulation of the FEF and PFv induced activation in common regions in the dorsolateral and medial frontal cortices, suggesting convergence of information processed in the two regions. Taken together, the results suggest dissociation between the FEF and PFv networks for their computational roles in perceptual decision making. The study also highlights the advantage of TMS-EEG technique in investigating the computational processes subserved by the neural network in the human brain with a high temporal resolution. |
| first_indexed | 2024-12-22T00:28:23Z |
| format | Article |
| id | doaj.art-448f6ae74bac4894a17796e60f5199a7 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T00:28:23Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-448f6ae74bac4894a17796e60f5199a72022-12-21T18:45:00ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-07-01710.3389/fnhum.2013.0036551141Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortexRei eAkaishi0Rei eAkaishi1Naoko eUeda2Katsuyuki eSakai3Graduate School of Medicine, The University of TokyoUniversity of OxfordGraduate School of Medicine, The University of TokyoGraduate School of Medicine, The University of TokyoThe dorsal and ventral parts of the lateral prefrontal cortex have been thought to play distinct roles in decision making. Although its dorsal part such as the frontal eye field (FEF) is shown to play roles in accumulation of sensory information during perceptual decision making, the role of the ventral prefrontal cortex (PFv) is not well-documented. Previous studies have suggested that the PFv is involved in selective attention to the task-relevant information and is associated with accuracy of the behavioral performance. It is unknown, however, whether the accumulation and selection processes are anatomically dissociated between the FEF and PFv. Here we show that, by using concurrent TMS and EEG recording, the short-latency (20 – 40 ms) TMS-evoked potentials after stimulation of the FEF change as a function of the time to behavioral response, whereas those after stimulation of the PFv change depending on whether the response is correct or not. The potentials after stimulation of either region did not show significant interaction between time to response and performance accuracy, suggesting dissociation between the processes subserved by the FEF and PFv networks. The results are consistent with the idea that the network involving the FEF plays a role in information accumulation, whereas the network involving the PFv plays a role in selecting task relevant information. In addition, stimulation of the FEF and PFv induced activation in common regions in the dorsolateral and medial frontal cortices, suggesting convergence of information processed in the two regions. Taken together, the results suggest dissociation between the FEF and PFv networks for their computational roles in perceptual decision making. The study also highlights the advantage of TMS-EEG technique in investigating the computational processes subserved by the neural network in the human brain with a high temporal resolution.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00365/fullElectroencephalographyTranscranial Magnetic Stimulationventral prefrontal cortexselectionfrontal eye fieldperceptual decision making |
| spellingShingle | Rei eAkaishi Rei eAkaishi Naoko eUeda Katsuyuki eSakai Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex Frontiers in Human Neuroscience Electroencephalography Transcranial Magnetic Stimulation ventral prefrontal cortex selection frontal eye field perceptual decision making |
| title | Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex |
| title_full | Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex |
| title_fullStr | Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex |
| title_full_unstemmed | Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex |
| title_short | Task-related modulation of effective connectivity during perceptual decision making: Dissociation between dorsal and ventral prefrontal cortex |
| title_sort | task related modulation of effective connectivity during perceptual decision making dissociation between dorsal and ventral prefrontal cortex |
| topic | Electroencephalography Transcranial Magnetic Stimulation ventral prefrontal cortex selection frontal eye field perceptual decision making |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00365/full |
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