Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation
Abstract Objective Gulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990–1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin ras...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-019-4855-2 |
| _version_ | 1818385545505538048 |
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| author | Tammy A. Butterick Janeen H. Trembley Laura L. Hocum Stone Clemma J. Muller Rebecca R. Rudquist Ronald R. Bach |
| author_facet | Tammy A. Butterick Janeen H. Trembley Laura L. Hocum Stone Clemma J. Muller Rebecca R. Rudquist Ronald R. Bach |
| author_sort | Tammy A. Butterick |
| collection | DOAJ |
| description | Abstract Objective Gulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990–1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin rashes. In our previous biomarker study, we discovered Gulf War Illness-associated proinflammatory blood biomarkers. Therefore, we hypothesized that chronic inflammation causes the symptoms that define this disorder. Testing the chronic inflammation hypothesis is the objective of this study. Results The biomarker fingerprint of Gulf War Illness is the end-product of a cascade of proinflammatory cytokine signals. In particular, the observed increase in C-reactive protein predicts a corresponding increase in interleukin 6, the cytokine that stimulates hepatocytes to produce C-reactive protein. Therefore, in this study we measured potential upstream cytokine signals in plasma samples from Gulf War Veterans. As predicted, a positive correlation between interleukin 6 and C-reactive protein was observed. |
| first_indexed | 2024-12-14T03:39:52Z |
| format | Article |
| id | doaj.art-44900d8d5fc74d1382a040c7a848bf59 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-14T03:39:52Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-44900d8d5fc74d1382a040c7a848bf592022-12-21T23:18:31ZengBMCBMC Research Notes1756-05002019-12-011211510.1186/s13104-019-4855-2Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammationTammy A. Butterick0Janeen H. Trembley1Laura L. Hocum Stone2Clemma J. Muller3Rebecca R. Rudquist4Ronald R. Bach5Minneapolis Veterans Affairs Health Care SystemMinneapolis Veterans Affairs Health Care SystemMinneapolis Veterans Affairs Health Care SystemElson S Floyd College of Medicine, Washington State UniversityMinneapolis Veterans Affairs Health Care SystemMinneapolis Veterans Affairs Health Care SystemAbstract Objective Gulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990–1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin rashes. In our previous biomarker study, we discovered Gulf War Illness-associated proinflammatory blood biomarkers. Therefore, we hypothesized that chronic inflammation causes the symptoms that define this disorder. Testing the chronic inflammation hypothesis is the objective of this study. Results The biomarker fingerprint of Gulf War Illness is the end-product of a cascade of proinflammatory cytokine signals. In particular, the observed increase in C-reactive protein predicts a corresponding increase in interleukin 6, the cytokine that stimulates hepatocytes to produce C-reactive protein. Therefore, in this study we measured potential upstream cytokine signals in plasma samples from Gulf War Veterans. As predicted, a positive correlation between interleukin 6 and C-reactive protein was observed.https://doi.org/10.1186/s13104-019-4855-2Gulf War IllnessChronic multisymptom illnessChronic inflammationBiomarkersProinflammatory cytokinesInterleukin 6 |
| spellingShingle | Tammy A. Butterick Janeen H. Trembley Laura L. Hocum Stone Clemma J. Muller Rebecca R. Rudquist Ronald R. Bach Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation BMC Research Notes Gulf War Illness Chronic multisymptom illness Chronic inflammation Biomarkers Proinflammatory cytokines Interleukin 6 |
| title | Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation |
| title_full | Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation |
| title_fullStr | Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation |
| title_full_unstemmed | Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation |
| title_short | Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation |
| title_sort | gulf war illness associated increases in blood levels of interleukin 6 and c reactive protein biomarker evidence of inflammation |
| topic | Gulf War Illness Chronic multisymptom illness Chronic inflammation Biomarkers Proinflammatory cytokines Interleukin 6 |
| url | https://doi.org/10.1186/s13104-019-4855-2 |
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