Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer
Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defendi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231717305451 |
| _version_ | 1828432166918291456 |
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| author | Luka Andrisic Danuta Dudzik Coral Barbas Lidija Milkovic Tilman Grune Neven Zarkovic |
| author_facet | Luka Andrisic Danuta Dudzik Coral Barbas Lidija Milkovic Tilman Grune Neven Zarkovic |
| author_sort | Luka Andrisic |
| collection | DOAJ |
| description | Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine. Keywords: Carcinogenesis, Cancer, Oxidative stress, Lipid peroxidation, 4-hydroxynonenal, Glutathione, Metabolomics, Immunochemistry, Biomarkers, Omics science |
| first_indexed | 2024-12-10T18:15:09Z |
| format | Article |
| id | doaj.art-44911ebda0884adb8ae24e8d75b8ef10 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-10T18:15:09Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-44911ebda0884adb8ae24e8d75b8ef102022-12-22T01:38:20ZengElsevierRedox Biology2213-23172018-04-01144758Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancerLuka Andrisic0Danuta Dudzik1Coral Barbas2Lidija Milkovic3Tilman Grune4Neven Zarkovic5CEMBIO (Centre for Metabolomics and Bioanalysis); Facultad de Farmacia; Universidad San Pablo CEU, Campus Montepríncipe, Madrid, Spain; Rudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for Oxidative Stress, Zagreb, CroatiaCEMBIO (Centre for Metabolomics and Bioanalysis); Facultad de Farmacia; Universidad San Pablo CEU, Campus Montepríncipe, Madrid, SpainCEMBIO (Centre for Metabolomics and Bioanalysis); Facultad de Farmacia; Universidad San Pablo CEU, Campus Montepríncipe, Madrid, SpainRudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for Oxidative Stress, Zagreb, CroatiaGerman Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, GermanyRudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for Oxidative Stress, Zagreb, Croatia; Corresponding author.Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine. Keywords: Carcinogenesis, Cancer, Oxidative stress, Lipid peroxidation, 4-hydroxynonenal, Glutathione, Metabolomics, Immunochemistry, Biomarkers, Omics sciencehttp://www.sciencedirect.com/science/article/pii/S2213231717305451 |
| spellingShingle | Luka Andrisic Danuta Dudzik Coral Barbas Lidija Milkovic Tilman Grune Neven Zarkovic Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer Redox Biology |
| title | Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| title_full | Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| title_fullStr | Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| title_full_unstemmed | Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| title_short | Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| title_sort | short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2213231717305451 |
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