BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease
The efficacy of SARS-CoV-2 mRNA-based vaccines in preventing COVID-19 disease has been extensively demonstrated; however, it is of uttermost importance to acquire knowledge on the persistence of immune-protection both in terms of levels of neutralizing antibodies and specialized memory cells. This c...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/10/1164 |
| _version_ | 1827678446909652992 |
|---|---|
| author | Claudia Rossi Paola Lanuti Ilaria Cicalini Domenico De Bellis Laura Pierdomenico Piero Del Boccio Mirco Zucchelli Luca Natale Bruna Sinjari Giulia Catitti Simone Vespa Pasquale Simeone Giuseppina Bologna Ines Bucci Katia Falasca Jacopo Vecchiet Liborio Stuppia Vincenzo De Laurenzi Damiana Pieragostino |
| author_facet | Claudia Rossi Paola Lanuti Ilaria Cicalini Domenico De Bellis Laura Pierdomenico Piero Del Boccio Mirco Zucchelli Luca Natale Bruna Sinjari Giulia Catitti Simone Vespa Pasquale Simeone Giuseppina Bologna Ines Bucci Katia Falasca Jacopo Vecchiet Liborio Stuppia Vincenzo De Laurenzi Damiana Pieragostino |
| author_sort | Claudia Rossi |
| collection | DOAJ |
| description | The efficacy of SARS-CoV-2 mRNA-based vaccines in preventing COVID-19 disease has been extensively demonstrated; however, it is of uttermost importance to acquire knowledge on the persistence of immune-protection both in terms of levels of neutralizing antibodies and specialized memory cells. This can provide important scientific basis for decisions on the need of additional vaccine doses and on when these should be administered thus resulting in an improvement in vaccination schedules. Here, we briefly report the changes in antibody levels and cellular immunity following BNT162b2 administration. We show an important fall in anti S1-Spike antibodies in BNT162b2 vaccinated subjects overtime, paralleled by a contextual consolidation of specific spike (S) T-cells, mainly of the CD8+ compartment. Contrariwise, CD4+ S-specific response shows a considerable interindividual variability. These data suggest that the well-known antibody drop in vaccinated subjects is replaced by memory cell consolidation that can protect from severe adverse effects of SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T06:09:19Z |
| format | Article |
| id | doaj.art-449149edc95c4d5c8e04ab7d1e3d6f4a |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T06:09:19Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-449149edc95c4d5c8e04ab7d1e3d6f4a2023-11-22T20:16:12ZengMDPI AGVaccines2076-393X2021-10-01910116410.3390/vaccines9101164BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 DiseaseClaudia Rossi0Paola Lanuti1Ilaria Cicalini2Domenico De Bellis3Laura Pierdomenico4Piero Del Boccio5Mirco Zucchelli6Luca Natale7Bruna Sinjari8Giulia Catitti9Simone Vespa10Pasquale Simeone11Giuseppina Bologna12Ines Bucci13Katia Falasca14Jacopo Vecchiet15Liborio Stuppia16Vincenzo De Laurenzi17Damiana Pieragostino18Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Medicine and Aging Science, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Medicine and Aging Science, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyThe efficacy of SARS-CoV-2 mRNA-based vaccines in preventing COVID-19 disease has been extensively demonstrated; however, it is of uttermost importance to acquire knowledge on the persistence of immune-protection both in terms of levels of neutralizing antibodies and specialized memory cells. This can provide important scientific basis for decisions on the need of additional vaccine doses and on when these should be administered thus resulting in an improvement in vaccination schedules. Here, we briefly report the changes in antibody levels and cellular immunity following BNT162b2 administration. We show an important fall in anti S1-Spike antibodies in BNT162b2 vaccinated subjects overtime, paralleled by a contextual consolidation of specific spike (S) T-cells, mainly of the CD8+ compartment. Contrariwise, CD4+ S-specific response shows a considerable interindividual variability. These data suggest that the well-known antibody drop in vaccinated subjects is replaced by memory cell consolidation that can protect from severe adverse effects of SARS-CoV-2 infection.https://www.mdpi.com/2076-393X/9/10/1164BNT162b2SARS-CoV-2vaccinesanti-S1 IgGspike-specific T-cells |
| spellingShingle | Claudia Rossi Paola Lanuti Ilaria Cicalini Domenico De Bellis Laura Pierdomenico Piero Del Boccio Mirco Zucchelli Luca Natale Bruna Sinjari Giulia Catitti Simone Vespa Pasquale Simeone Giuseppina Bologna Ines Bucci Katia Falasca Jacopo Vecchiet Liborio Stuppia Vincenzo De Laurenzi Damiana Pieragostino BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease Vaccines BNT162b2 SARS-CoV-2 vaccines anti-S1 IgG spike-specific T-cells |
| title | BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease |
| title_full | BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease |
| title_fullStr | BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease |
| title_full_unstemmed | BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease |
| title_short | BNT162b2 mRNA Vaccination Leads to Long-Term Protection from COVID-19 Disease |
| title_sort | bnt162b2 mrna vaccination leads to long term protection from covid 19 disease |
| topic | BNT162b2 SARS-CoV-2 vaccines anti-S1 IgG spike-specific T-cells |
| url | https://www.mdpi.com/2076-393X/9/10/1164 |
| work_keys_str_mv | AT claudiarossi bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT paolalanuti bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT ilariacicalini bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT domenicodebellis bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT laurapierdomenico bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT pierodelboccio bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT mircozucchelli bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT lucanatale bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT brunasinjari bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT giuliacatitti bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT simonevespa bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT pasqualesimeone bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT giuseppinabologna bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT inesbucci bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT katiafalasca bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT jacopovecchiet bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT liboriostuppia bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT vincenzodelaurenzi bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease AT damianapieragostino bnt162b2mrnavaccinationleadstolongtermprotectionfromcovid19disease |