Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer
Abstract Abstract Parkinson disease (PD) is associated with a variety of motor and non-motor clinical manifestations, including cardiovascular autonomic dysfunction. Neurogenic orthostatic hypotension (nOH) is a potentially serious manifestation of cardiovascular sympathetic failure that occurs in a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-08-01
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| Series: | Neurology and Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s40120-019-00152-9 |
| _version_ | 1818409227826233344 |
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| author | Jeremy K. Cutsforth-Gregory Phillip A. Low |
| author_facet | Jeremy K. Cutsforth-Gregory Phillip A. Low |
| author_sort | Jeremy K. Cutsforth-Gregory |
| collection | DOAJ |
| description | Abstract Abstract Parkinson disease (PD) is associated with a variety of motor and non-motor clinical manifestations, including cardiovascular autonomic dysfunction. Neurogenic orthostatic hypotension (nOH) is a potentially serious manifestation of cardiovascular sympathetic failure that occurs in approximately 30% of patients with PD. Here we review the pathophysiology and effects of the condition as well as treatment considerations for patients with PD and nOH. Screening for nOH using orthostatic symptom questionnaires, orthostatic blood pressure measurements, and specialized autonomic testing is beneficial for the identification of symptomatic and asymptomatic cases because cardiac sympathetic denervation and nOH can occur even at early (premotor) stages of PD. Symptoms of nOH, such as orthostatic lightheadedness, in patients with PD, have been shown to adversely affect patient safety (with increased risk of falls) and quality of life and should prompt treatment with non-pharmacologic and, occasionally, pharmacologic measures. Patients with nOH are also at increased risk of supine hypertension, which requires balancing various management strategies. Funding Lundbeck (Deerfield, IL). |
| first_indexed | 2024-12-14T09:56:17Z |
| format | Article |
| id | doaj.art-4499735d327e4b45a82e4491bfbb113d |
| institution | Directory Open Access Journal |
| issn | 2193-8253 2193-6536 |
| language | English |
| last_indexed | 2024-12-14T09:56:17Z |
| publishDate | 2019-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Neurology and Therapy |
| spelling | doaj.art-4499735d327e4b45a82e4491bfbb113d2022-12-21T23:07:22ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362019-08-018230732410.1007/s40120-019-00152-9Neurogenic Orthostatic Hypotension in Parkinson Disease: A PrimerJeremy K. Cutsforth-Gregory0Phillip A. Low1Department of Neurology, Mayo ClinicDepartment of Neurology, Mayo ClinicAbstract Abstract Parkinson disease (PD) is associated with a variety of motor and non-motor clinical manifestations, including cardiovascular autonomic dysfunction. Neurogenic orthostatic hypotension (nOH) is a potentially serious manifestation of cardiovascular sympathetic failure that occurs in approximately 30% of patients with PD. Here we review the pathophysiology and effects of the condition as well as treatment considerations for patients with PD and nOH. Screening for nOH using orthostatic symptom questionnaires, orthostatic blood pressure measurements, and specialized autonomic testing is beneficial for the identification of symptomatic and asymptomatic cases because cardiac sympathetic denervation and nOH can occur even at early (premotor) stages of PD. Symptoms of nOH, such as orthostatic lightheadedness, in patients with PD, have been shown to adversely affect patient safety (with increased risk of falls) and quality of life and should prompt treatment with non-pharmacologic and, occasionally, pharmacologic measures. Patients with nOH are also at increased risk of supine hypertension, which requires balancing various management strategies. Funding Lundbeck (Deerfield, IL).http://link.springer.com/article/10.1007/s40120-019-00152-9Non-motor symptoms of Parkinson diseaseOrthostatic hypotensionScreeningSupine hypertensionTreatment |
| spellingShingle | Jeremy K. Cutsforth-Gregory Phillip A. Low Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer Neurology and Therapy Non-motor symptoms of Parkinson disease Orthostatic hypotension Screening Supine hypertension Treatment |
| title | Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer |
| title_full | Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer |
| title_fullStr | Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer |
| title_full_unstemmed | Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer |
| title_short | Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer |
| title_sort | neurogenic orthostatic hypotension in parkinson disease a primer |
| topic | Non-motor symptoms of Parkinson disease Orthostatic hypotension Screening Supine hypertension Treatment |
| url | http://link.springer.com/article/10.1007/s40120-019-00152-9 |
| work_keys_str_mv | AT jeremykcutsforthgregory neurogenicorthostatichypotensioninparkinsondiseaseaprimer AT phillipalow neurogenicorthostatichypotensioninparkinsondiseaseaprimer |