ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

G-protein-coupled receptors (GPCRs) are known to activate both G protein- and β-arrestin-dependent signalling cascades. The initiation of mitogen-activated protein kinase (MAPK) pathways is a key downstream event in the control of cellular functions including proliferation, differentiation, migratio...

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Bibliographic Details
Main Authors: Guzmán Sánchez-Fernández, Sofía Cabezudo, Carlota García-Hoz, Andrew B Tobin, Federico Mayor, Catalina Ribas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866124?pdf=render

Internet

http://europepmc.org/articles/PMC3866124?pdf=render

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