371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review
OBJECTIVES/GOALS: Penetrating brain injury (PBI) differs both physiologically and in clinical outcomes when compared to blunt-force traumatic brain injury (TBI). Despite this, there are few pre-clinical models of PBI described in the literature. To address this gap, we will develop a study protocol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866124003285/type/journal_article |
| _version_ | 1797226954080911360 |
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| author | Roy A. Poblete Stan G. Louie Gene Sung Patrick D. Lyden |
| author_facet | Roy A. Poblete Stan G. Louie Gene Sung Patrick D. Lyden |
| author_sort | Roy A. Poblete |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Penetrating brain injury (PBI) differs both physiologically and in clinical outcomes when compared to blunt-force traumatic brain injury (TBI). Despite this, there are few pre-clinical models of PBI described in the literature. To address this gap, we will develop a study protocol for a systematic review. METHODS/STUDY POPULATION: Three electronic databases (PubMed, Embase, Web of Science) will be searched using keywords and controlled vocabulary related to animal models, computational models, simulations, and disease key words including traumatic brain injury and penetrating brain injury. The primary outcome will be the method of PBI modeling. Secondary outcomes will be related to bibliographic information, computational analysis, and histochemical, radiographic, behavioral, and human clinical biomarkers and outcome measures used in PBI models. A panel of independent investigators will review publications resulting from this search strategy to identify relevant studies. The protocol will adhere to PRISMA-P guidelines. RESULTS/ANTICIPATED RESULTS: Eligible studies will include both exploratory and descriptive research, and both quantitative and qualitative data. A summary of selected studies will be presented, and the synthesis will follow a narrative framework. DISCUSSION/SIGNIFICANCE: This protocol provides a framework for comprehensively evaluating pre-clinical PBI models with focus on methodology. PBI is a phenotypically unique disease and is under studied. This protocol will be of great benefit to clinicians and scientists in this emerging field and can help monitor future progress in translational research. |
| first_indexed | 2024-04-24T14:33:06Z |
| format | Article |
| id | doaj.art-449e06dfb3324636bbac76745b534be6 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-24T14:33:06Z |
| publishDate | 2024-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-449e06dfb3324636bbac76745b534be62024-04-03T01:59:55ZengCambridge University PressJournal of Clinical and Translational Science2059-86612024-04-01811211210.1017/cts.2024.328371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic ReviewRoy A. Poblete0Stan G. Louie1Gene Sung2Patrick D. Lyden3Unversity of Southern CaliforniaUnversity of Southern CaliforniaUnversity of Southern CaliforniaUnversity of Southern CaliforniaOBJECTIVES/GOALS: Penetrating brain injury (PBI) differs both physiologically and in clinical outcomes when compared to blunt-force traumatic brain injury (TBI). Despite this, there are few pre-clinical models of PBI described in the literature. To address this gap, we will develop a study protocol for a systematic review. METHODS/STUDY POPULATION: Three electronic databases (PubMed, Embase, Web of Science) will be searched using keywords and controlled vocabulary related to animal models, computational models, simulations, and disease key words including traumatic brain injury and penetrating brain injury. The primary outcome will be the method of PBI modeling. Secondary outcomes will be related to bibliographic information, computational analysis, and histochemical, radiographic, behavioral, and human clinical biomarkers and outcome measures used in PBI models. A panel of independent investigators will review publications resulting from this search strategy to identify relevant studies. The protocol will adhere to PRISMA-P guidelines. RESULTS/ANTICIPATED RESULTS: Eligible studies will include both exploratory and descriptive research, and both quantitative and qualitative data. A summary of selected studies will be presented, and the synthesis will follow a narrative framework. DISCUSSION/SIGNIFICANCE: This protocol provides a framework for comprehensively evaluating pre-clinical PBI models with focus on methodology. PBI is a phenotypically unique disease and is under studied. This protocol will be of great benefit to clinicians and scientists in this emerging field and can help monitor future progress in translational research.https://www.cambridge.org/core/product/identifier/S2059866124003285/type/journal_article |
| spellingShingle | Roy A. Poblete Stan G. Louie Gene Sung Patrick D. Lyden 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review Journal of Clinical and Translational Science |
| title | 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review |
| title_full | 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review |
| title_fullStr | 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review |
| title_full_unstemmed | 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review |
| title_short | 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review |
| title_sort | 371 pre clinical models of penetrating brain injury study protocol for a systematic review |
| url | https://www.cambridge.org/core/product/identifier/S2059866124003285/type/journal_article |
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