Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices
<i>Background and Objectives</i>: The aim of this study was to report the characteristics of macular neovascularization (MNV) with undetectable flow on optical coherence tomography angiography (OCTA) in neovascular age related macular degeneration (nAMD), and compare them with the charac...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/1648-9144/58/9/1246 |
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| author | Meryem Filali Ansary Emanuele Crincoli Oudy Semoun Joel Uzzan Francesca Amoroso Camille Jung Alexandra Miere Eric Souied |
| author_facet | Meryem Filali Ansary Emanuele Crincoli Oudy Semoun Joel Uzzan Francesca Amoroso Camille Jung Alexandra Miere Eric Souied |
| author_sort | Meryem Filali Ansary |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The aim of this study was to report the characteristics of macular neovascularization (MNV) with undetectable flow on optical coherence tomography angiography (OCTA) in neovascular age related macular degeneration (nAMD), and compare them with the characteristics of detectable MNV. <i>Materials and Methods</i>: Patients with a diagnosis of nAMD who underwent dye imaging and OCTA in the same day were included and divided into two groups: undetectable and detectable flow on OCTA. Three OCTA devices were used, two with spectral-domain technology (AngioVue, RTVue 100xAvanti, Optovue, Freemont, CA, USA and Heidelberg OCT2 Beta Angiography Module, Heidelberg Engineering, Germany) and one swept-source OCTA (PlexElite 9000; Carl Zeiss Meditec, Inc., Dublin, CA, USA). We studied the demographics, neovascularization characteristics, and OCTA device and acquisition characteristics for both groups. <i>Results</i>: A global comparison between Group 1 and Group 2 was made, followed by an analysis of variables associated with (un)detectability for each OCTA device. A total of 108 eyes were included: 90 in the detectable group (Group 1) and 18 in the undetectable group (Group 2), corresponding to a global sensitivity of OCTA for the detection of MNV of 83.49%. There was a statistically significant difference between the two groups regarding MNV type (<i>p</i> = 0.02) and PED height (<i>p</i> = 0.017). For the three devices, detection sensitivity with automatic segmentation was significantly lower than with manual segmentation. For Heidelberg, PED Height and scan quality explained 68.3% of the undetectability. For AngioVue, PED Height and absence of hemorrhage explained 67.9% of undetectability. <i>Conclusions</i>: In this study, we found a global sensitivity of 83.49% for the three OCTA devices combined, with a range from 55.5% to 96.26% depending on the segmentation and OCTA device. This means that undetectable/undetected MNV can represent up to 45% of the examinations, eventually misdiagnosing choroidal neovascularization for 1 out every 2 patients. |
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| spelling | doaj.art-449e410ec27742308827d102311007972023-11-23T17:40:22ZengMDPI AGMedicina1010-660X1648-91442022-09-01589124610.3390/medicina58091246Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different DevicesMeryem Filali Ansary0Emanuele Crincoli1Oudy Semoun2Joel Uzzan3Francesca Amoroso4Camille Jung5Alexandra Miere6Eric Souied7Department of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceCenter of Clinical Research, Centre Hospitalier Intercommunal de Créteil, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, FranceDepartment of Ophthalmology, Creteil University Eye Clinic, Hopital Intercommunal de Creteil, University Paris Est, 40 Avenue de Verdun, 94010 Creteil, France<i>Background and Objectives</i>: The aim of this study was to report the characteristics of macular neovascularization (MNV) with undetectable flow on optical coherence tomography angiography (OCTA) in neovascular age related macular degeneration (nAMD), and compare them with the characteristics of detectable MNV. <i>Materials and Methods</i>: Patients with a diagnosis of nAMD who underwent dye imaging and OCTA in the same day were included and divided into two groups: undetectable and detectable flow on OCTA. Three OCTA devices were used, two with spectral-domain technology (AngioVue, RTVue 100xAvanti, Optovue, Freemont, CA, USA and Heidelberg OCT2 Beta Angiography Module, Heidelberg Engineering, Germany) and one swept-source OCTA (PlexElite 9000; Carl Zeiss Meditec, Inc., Dublin, CA, USA). We studied the demographics, neovascularization characteristics, and OCTA device and acquisition characteristics for both groups. <i>Results</i>: A global comparison between Group 1 and Group 2 was made, followed by an analysis of variables associated with (un)detectability for each OCTA device. A total of 108 eyes were included: 90 in the detectable group (Group 1) and 18 in the undetectable group (Group 2), corresponding to a global sensitivity of OCTA for the detection of MNV of 83.49%. There was a statistically significant difference between the two groups regarding MNV type (<i>p</i> = 0.02) and PED height (<i>p</i> = 0.017). For the three devices, detection sensitivity with automatic segmentation was significantly lower than with manual segmentation. For Heidelberg, PED Height and scan quality explained 68.3% of the undetectability. For AngioVue, PED Height and absence of hemorrhage explained 67.9% of undetectability. <i>Conclusions</i>: In this study, we found a global sensitivity of 83.49% for the three OCTA devices combined, with a range from 55.5% to 96.26% depending on the segmentation and OCTA device. This means that undetectable/undetected MNV can represent up to 45% of the examinations, eventually misdiagnosing choroidal neovascularization for 1 out every 2 patients.https://www.mdpi.com/1648-9144/58/9/1246optical coherence tomography (OCT)OCT-angiography (OCTA)macular neovascularizationspectral-domain OCTAswept-source OCTA |
| spellingShingle | Meryem Filali Ansary Emanuele Crincoli Oudy Semoun Joel Uzzan Francesca Amoroso Camille Jung Alexandra Miere Eric Souied Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices Medicina optical coherence tomography (OCT) OCT-angiography (OCTA) macular neovascularization spectral-domain OCTA swept-source OCTA |
| title | Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices |
| title_full | Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices |
| title_fullStr | Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices |
| title_full_unstemmed | Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices |
| title_short | Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices |
| title_sort | undetectable macular neovascularization on oct angiography in age related macular degeneration comparison between different devices |
| topic | optical coherence tomography (OCT) OCT-angiography (OCTA) macular neovascularization spectral-domain OCTA swept-source OCTA |
| url | https://www.mdpi.com/1648-9144/58/9/1246 |
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