Efeito do alumínio na oxidação não enzimática da dopamina.
The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1994-11-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984 |
| _version_ | 1811242266435518464 |
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| author | C R Marinho C F Manso |
| author_facet | C R Marinho C F Manso |
| author_sort | C R Marinho |
| collection | DOAJ |
| description | The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues. |
| first_indexed | 2024-04-12T13:49:14Z |
| format | Article |
| id | doaj.art-449e4831b0cd4cf6b333a38dc8ff4bc6 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:49:14Z |
| publishDate | 1994-11-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-449e4831b0cd4cf6b333a38dc8ff4bc62022-12-22T03:30:35ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581994-11-0171110.20344/amp.2984Efeito do alumínio na oxidação não enzimática da dopamina.C R Marinho0C F MansoInstituto de Química Fisiológica, Faculdade de Medicina de Lisboa.The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984 |
| spellingShingle | C R Marinho C F Manso Efeito do alumínio na oxidação não enzimática da dopamina. Acta Médica Portuguesa |
| title | Efeito do alumínio na oxidação não enzimática da dopamina. |
| title_full | Efeito do alumínio na oxidação não enzimática da dopamina. |
| title_fullStr | Efeito do alumínio na oxidação não enzimática da dopamina. |
| title_full_unstemmed | Efeito do alumínio na oxidação não enzimática da dopamina. |
| title_short | Efeito do alumínio na oxidação não enzimática da dopamina. |
| title_sort | efeito do aluminio na oxidacao nao enzimatica da dopamina |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984 |
| work_keys_str_mv | AT crmarinho efeitodoaluminionaoxidacaonaoenzimaticadadopamina AT cfmanso efeitodoaluminionaoxidacaonaoenzimaticadadopamina |