Different Treatment Modalities of Oral Lichen Planus—A Narrative Review
Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which affects the oral mucosa. OLP varies in its clinical features from a reticular form that is, in most cases, asymptomatic, to atrophic–erosive, and is accompanied by symptoms of burning sensation and pain followed by...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/11/1/26 |
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| author | Ana Andabak-Rogulj Ema Vindiš Lorena Horvat Aleksijević Ivana Škrinjar Danica Vidović Juras Anastazija Aščić Božana Lončar Brzak |
| author_facet | Ana Andabak-Rogulj Ema Vindiš Lorena Horvat Aleksijević Ivana Škrinjar Danica Vidović Juras Anastazija Aščić Božana Lončar Brzak |
| author_sort | Ana Andabak-Rogulj |
| collection | DOAJ |
| description | Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which affects the oral mucosa. OLP varies in its clinical features from a reticular form that is, in most cases, asymptomatic, to atrophic–erosive, and is accompanied by symptoms of burning sensation and pain followed by difficulty in eating. Given the fact that OLP is a disease of unknown etiology, the treatment is symptomatic and involves suppressing the signs and symptoms of the disease using various topical and systemic drugs. The first line of therapy for treating symptomatic OLP is topical corticosteroids, whereas systemic corticosteroids are used for treating persistent lesions that do not respond to local treatment. However, the lack of convincing evidence on the efficacy of previous therapies, including topical corticosteroids, and numerous side effects that have appeared over recent years has resulted in the emergence and development of new therapeutic options. Some of the therapies mentioned are tacrolimus, efalizumab, dapson, interferon, retinoic acid, photochemotherapy with psoralen and ultraviolet A rays (PUVA), aloe vera, antimalarials, antibiotics and others. These therapies only partially meet the properties of efficacy and safety of use, thus justifying the continuous search and testing of new treatment methods. |
| first_indexed | 2024-03-09T13:03:37Z |
| format | Article |
| id | doaj.art-449e68299ba94d2eac224f0ff198c1bf |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T13:03:37Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-449e68299ba94d2eac224f0ff198c1bf2023-11-30T21:51:09ZengMDPI AGDentistry Journal2304-67672023-01-011112610.3390/dj11010026Different Treatment Modalities of Oral Lichen Planus—A Narrative ReviewAna Andabak-Rogulj0Ema Vindiš1Lorena Horvat Aleksijević2Ivana Škrinjar3Danica Vidović Juras4Anastazija Aščić5Božana Lončar Brzak6Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDental Practice at Healthcare Center Ormož, 2270 Ormož, SloveniaFaculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, CroatiaDepartment of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaPrivate Dental Practice, 31000 Osijek, CroatiaDepartment of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaOral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which affects the oral mucosa. OLP varies in its clinical features from a reticular form that is, in most cases, asymptomatic, to atrophic–erosive, and is accompanied by symptoms of burning sensation and pain followed by difficulty in eating. Given the fact that OLP is a disease of unknown etiology, the treatment is symptomatic and involves suppressing the signs and symptoms of the disease using various topical and systemic drugs. The first line of therapy for treating symptomatic OLP is topical corticosteroids, whereas systemic corticosteroids are used for treating persistent lesions that do not respond to local treatment. However, the lack of convincing evidence on the efficacy of previous therapies, including topical corticosteroids, and numerous side effects that have appeared over recent years has resulted in the emergence and development of new therapeutic options. Some of the therapies mentioned are tacrolimus, efalizumab, dapson, interferon, retinoic acid, photochemotherapy with psoralen and ultraviolet A rays (PUVA), aloe vera, antimalarials, antibiotics and others. These therapies only partially meet the properties of efficacy and safety of use, thus justifying the continuous search and testing of new treatment methods.https://www.mdpi.com/2304-6767/11/1/26oral lichen planuschronic diseasetherapeuticsadverse effects |
| spellingShingle | Ana Andabak-Rogulj Ema Vindiš Lorena Horvat Aleksijević Ivana Škrinjar Danica Vidović Juras Anastazija Aščić Božana Lončar Brzak Different Treatment Modalities of Oral Lichen Planus—A Narrative Review Dentistry Journal oral lichen planus chronic disease therapeutics adverse effects |
| title | Different Treatment Modalities of Oral Lichen Planus—A Narrative Review |
| title_full | Different Treatment Modalities of Oral Lichen Planus—A Narrative Review |
| title_fullStr | Different Treatment Modalities of Oral Lichen Planus—A Narrative Review |
| title_full_unstemmed | Different Treatment Modalities of Oral Lichen Planus—A Narrative Review |
| title_short | Different Treatment Modalities of Oral Lichen Planus—A Narrative Review |
| title_sort | different treatment modalities of oral lichen planus a narrative review |
| topic | oral lichen planus chronic disease therapeutics adverse effects |
| url | https://www.mdpi.com/2304-6767/11/1/26 |
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