Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury
Aim of the research is to evaluate the structure changes of the capillaries, arterioles, venules and intra and extravascular alterations in myocardium of rats after traumatic brain injury (TBI).Material and methods. Experiments were performed in 18 white male noninbred rats. Midline thoracotomy was...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2016-07-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1518 |
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| author | G. A. Boyarinov A. V. Deryugina R. R. Zaytsev L. V. Boyarinova E. I. Yakovleva O. D. Soloveva V. O. Nikolskiy M. V. Galkina A. A. Martusevich |
| author_facet | G. A. Boyarinov A. V. Deryugina R. R. Zaytsev L. V. Boyarinova E. I. Yakovleva O. D. Soloveva V. O. Nikolskiy M. V. Galkina A. A. Martusevich |
| author_sort | G. A. Boyarinov |
| collection | DOAJ |
| description | Aim of the research is to evaluate the structure changes of the capillaries, arterioles, venules and intra and extravascular alterations in myocardium of rats after traumatic brain injury (TBI).Material and methods. Experiments were performed in 18 white male noninbred rats. Midline thoracotomy was performed, and the heart excised under intraperitoneal anesthesia (sodium thiopental) on 3, 7 and 12 days after TBI. Myocardial tissue of the left ventricle was examined under light and electron microscopy.The results showed that following brain trauma there were changes of microvascular wall characterized by alterations of permeability, paracellular oedema, outgrowths of vessel endothelium, swelling, edema, and thinning of endothelial cells, intussusceptions, vacuolization of cytoplasm with fragmentation within the myocardium of the rats with TBI. Intravascular changes were manifested by the formation of hyaline thrombi, microaggregates and sludge of red blood cells in the lumen, altered vascular membrane structures, bubbles or even complete absence of circulation in capillaries (noreflow). Alterations outside of the vascular wall were manifested by the formation of diapedetic hemorrhage and development of a strongly pronounced perivascular edema. The injury of microvessels and the microrelief of the luminal surface of endothelial cells appeared to be important factors of activation of vascularplatelet mechanism of hemostasis.Conclusion. Treatment of traumatic disease should consider the need in timely correction of nonspecific alter ations associated with TBI to optimize the restructuring of cytoskeleton of endothelial cells, abrogate endothelial dysfunction and prevent microcirculatory complications. |
| first_indexed | 2024-04-10T01:28:05Z |
| format | Article |
| id | doaj.art-449ed4ae8f0041eb91816647d18159ca |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:28:05Z |
| publishDate | 2016-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-449ed4ae8f0041eb91816647d18159ca2023-03-13T09:32:54ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102016-07-01122202910.15360/1813-9779-2016-2-20-291496Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral InjuryG. A. Boyarinov0A. V. Deryugina1R. R. Zaytsev2L. V. Boyarinova3E. I. Yakovleva4O. D. Soloveva5V. O. Nikolskiy6M. V. Galkina7A. A. Martusevich8Нижегородская государственная медицинская академия Минздрава РоссииНациональный исследовательский Нижегородский государственный университет им. Н. И. ЛобачевскогоНижегородская государственная медицинская академия Минздрава РоссииНижегородская государственная медицинская академия Минздрава РоссииНижегородская государственная медицинская академия Минздрава РоссииНижегородская государственная медицинская академия Минздрава РоссииНациональный исследовательский Нижегородский государственный университет им. Н. И. ЛобачевскогоНижегородская государственная медицинская академия Минздрава РоссииНациональный исследовательский Нижегородский государственный университет им. Н. И. ЛобачевскогоAim of the research is to evaluate the structure changes of the capillaries, arterioles, venules and intra and extravascular alterations in myocardium of rats after traumatic brain injury (TBI).Material and methods. Experiments were performed in 18 white male noninbred rats. Midline thoracotomy was performed, and the heart excised under intraperitoneal anesthesia (sodium thiopental) on 3, 7 and 12 days after TBI. Myocardial tissue of the left ventricle was examined under light and electron microscopy.The results showed that following brain trauma there were changes of microvascular wall characterized by alterations of permeability, paracellular oedema, outgrowths of vessel endothelium, swelling, edema, and thinning of endothelial cells, intussusceptions, vacuolization of cytoplasm with fragmentation within the myocardium of the rats with TBI. Intravascular changes were manifested by the formation of hyaline thrombi, microaggregates and sludge of red blood cells in the lumen, altered vascular membrane structures, bubbles or even complete absence of circulation in capillaries (noreflow). Alterations outside of the vascular wall were manifested by the formation of diapedetic hemorrhage and development of a strongly pronounced perivascular edema. The injury of microvessels and the microrelief of the luminal surface of endothelial cells appeared to be important factors of activation of vascularplatelet mechanism of hemostasis.Conclusion. Treatment of traumatic disease should consider the need in timely correction of nonspecific alter ations associated with TBI to optimize the restructuring of cytoskeleton of endothelial cells, abrogate endothelial dysfunction and prevent microcirculatory complications.https://www.reanimatology.com/rmt/article/view/1518черепномозговая травмаповреждения капилляровартериол и венул миокарда |
| spellingShingle | G. A. Boyarinov A. V. Deryugina R. R. Zaytsev L. V. Boyarinova E. I. Yakovleva O. D. Soloveva V. O. Nikolskiy M. V. Galkina A. A. Martusevich Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury Общая реаниматология черепномозговая травма повреждения капилляров артериол и венул миокарда |
| title | Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury |
| title_full | Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury |
| title_fullStr | Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury |
| title_full_unstemmed | Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury |
| title_short | Morphological Changes in Myocardial Blood Microvessels in Experimental Craniocerebral Injury |
| title_sort | morphological changes in myocardial blood microvessels in experimental craniocerebral injury |
| topic | черепномозговая травма повреждения капилляров артериол и венул миокарда |
| url | https://www.reanimatology.com/rmt/article/view/1518 |
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