Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice
Circulating 25-hydroxyvitamin D (25(OH)D) is regarded as the most reliable biomarker of vitamin D status. However, limited data exist concerning the suitability of 25(OH)D as an indicator of body vitamin D stores and the ability of adipose tissue to mobilize vitamin D. In the first study, in which m...
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2020-05-01
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author | Mikis Kiourtzidis Julia Kühn Corinna Brandsch Anja-Christina Baur Monika Wensch-Dorendorf Gabriele I. Stangl |
author_facet | Mikis Kiourtzidis Julia Kühn Corinna Brandsch Anja-Christina Baur Monika Wensch-Dorendorf Gabriele I. Stangl |
author_sort | Mikis Kiourtzidis |
collection | DOAJ |
description | Circulating 25-hydroxyvitamin D (25(OH)D) is regarded as the most reliable biomarker of vitamin D status. However, limited data exist concerning the suitability of 25(OH)D as an indicator of body vitamin D stores and the ability of adipose tissue to mobilize vitamin D. In the first study, in which male mice received different vitamin D<sub>3</sub> doses for three weeks, we found strong linear response relationships between vitamin D<sub>3</sub> intake and levels of vitamin D<sub>3</sub> in the plasma (<i>p</i> < 0.001), liver (<i>p</i> < 0.001) and adipose tissues (<i>p</i> < 0.001), and strong positive correlations between plasma and tissue stores of vitamin D<sub>3</sub> (<i>p</i> < 0.001). Plasma levels of 25(OH)D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> (24,25(OH)<sub>2</sub>D<sub>3</sub>) showed weak or no correlations with tissue vitamin D<sub>3</sub> stores. Data from a second study demonstrate a strong and rapid response of plasma 25(OH)D<sub>3</sub> in vitamin D<sub>3</sub>-treated mice with a low vitamin D status. Additionally, mice fed a vitamin D-free diet showed a strong and rapid decline in vitamin D<sub>3</sub> in the liver, whereas the decline in different adipose tissues was distinctly lower than that in the liver. To conclude, tissue stores of vitamin D<sub>3</sub> were best reflected by plasma vitamin D<sub>3</sub>. In contrast to the liver, adipose tissues responded less sensitively to an absence of vitamin D intake. |
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spelling | doaj.art-44a001d8a65242d38ab10f723e126b112023-11-20T00:14:50ZengMDPI AGNutrients2072-66432020-05-01125139110.3390/nu12051391Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male MiceMikis Kiourtzidis0Julia Kühn1Corinna Brandsch2Anja-Christina Baur3Monika Wensch-Dorendorf4Gabriele I. Stangl5Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), GermanyCirculating 25-hydroxyvitamin D (25(OH)D) is regarded as the most reliable biomarker of vitamin D status. However, limited data exist concerning the suitability of 25(OH)D as an indicator of body vitamin D stores and the ability of adipose tissue to mobilize vitamin D. In the first study, in which male mice received different vitamin D<sub>3</sub> doses for three weeks, we found strong linear response relationships between vitamin D<sub>3</sub> intake and levels of vitamin D<sub>3</sub> in the plasma (<i>p</i> < 0.001), liver (<i>p</i> < 0.001) and adipose tissues (<i>p</i> < 0.001), and strong positive correlations between plasma and tissue stores of vitamin D<sub>3</sub> (<i>p</i> < 0.001). Plasma levels of 25(OH)D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> (24,25(OH)<sub>2</sub>D<sub>3</sub>) showed weak or no correlations with tissue vitamin D<sub>3</sub> stores. Data from a second study demonstrate a strong and rapid response of plasma 25(OH)D<sub>3</sub> in vitamin D<sub>3</sub>-treated mice with a low vitamin D status. Additionally, mice fed a vitamin D-free diet showed a strong and rapid decline in vitamin D<sub>3</sub> in the liver, whereas the decline in different adipose tissues was distinctly lower than that in the liver. To conclude, tissue stores of vitamin D<sub>3</sub> were best reflected by plasma vitamin D<sub>3</sub>. In contrast to the liver, adipose tissues responded less sensitively to an absence of vitamin D intake.https://www.mdpi.com/2072-6643/12/5/139125(OH)Dadipose tissuelivermicevitamin D |
spellingShingle | Mikis Kiourtzidis Julia Kühn Corinna Brandsch Anja-Christina Baur Monika Wensch-Dorendorf Gabriele I. Stangl Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice Nutrients 25(OH)D adipose tissue liver mice vitamin D |
title | Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice |
title_full | Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice |
title_fullStr | Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice |
title_full_unstemmed | Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice |
title_short | Markers Indicating Body Vitamin D Stores and Responses of Liver and Adipose Tissues to Changes in Vitamin D Intake in Male Mice |
title_sort | markers indicating body vitamin d stores and responses of liver and adipose tissues to changes in vitamin d intake in male mice |
topic | 25(OH)D adipose tissue liver mice vitamin D |
url | https://www.mdpi.com/2072-6643/12/5/1391 |
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