Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels
Purpose: This study explored the association between peripheral blood oxytocin (OT) and social anxiety disorder (SAD) and cue-induced cravings in female heroin addicts. The effect of exercise on alleviation of SAD and OT levels was also explored.Methods: A total of 72 females with heroin dependence...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.624993/full |
| _version_ | 1818734555960442880 |
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| author | Jing Song Wang Jing Lin Liu Jun Zhang Jun Tan Ting Huang Chun Xia Lu Xi Yang Peng Yin Guo Lan Zheng |
| author_facet | Jing Song Wang Jing Lin Liu Jun Zhang Jun Tan Ting Huang Chun Xia Lu Xi Yang Peng Yin Guo Lan Zheng |
| author_sort | Jing Song Wang |
| collection | DOAJ |
| description | Purpose: This study explored the association between peripheral blood oxytocin (OT) and social anxiety disorder (SAD) and cue-induced cravings in female heroin addicts. The effect of exercise on alleviation of SAD and OT levels was also explored.Methods: A total of 72 females with heroin dependence were assigned to three groups based on SAD severity. The three groups were Non-SAD control, SAD control, and SAD exercise groups. Subjects in the SAD exercise group underwent aerobic exercise and resistance training for 8 weeks (60 min/day, 5 days/week). Enzyme-linked immunosorbent assay analysis and Liebowitz Social Anxiety Scale (LSAS) scores were used to determine plasma OT concentration and SAD, respectively. Cue-induced craving was assessed using Visual Analog Scale (VAS) and Desires for Drug Questionnaire (DDQ). Mixed-effect analysis of variance and Pearson correlation analysis were used to explore the effect and correlation between different parameters.Results: OT levels in the SAD exercise group were significantly high after exercise (p < 0.01). LSAS, VAS, and DDQ (“Desire and Intention” and “Negative reinforcement”) scores in the SAD exercise group were significantly lower after exercise (p < 0.01). Plasma OT level was negatively correlated with LSAS score (r = −0.534, p < 0.001), VAS score (r = −0.609, p < 0.001), “Desire and Intention” score (r = −0.555, p < 0.001), and “Negative reinforcement” score (r = −0.332, p < 0.01) and positively correlated with the “control” score (r = 0.258, p < 0.05). LSAS was positively correlated with VAS score (r = 0.588, p < 0.001) and “Desire and Intention” score (r = 0.282, p < 0.05).Conclusions: The findings of the present study indicate that plasma OT is a potential peripheral biomarker for prediction of the severity of social anxiety in female heroin withdrawal patients. Aerobic exercise combined with resistance training plus incremental load for 8 weeks can increase plasma OT levels and significantly reduce severity of SAD and cue-induced cravings in female heroin addicts. |
| first_indexed | 2024-12-18T00:07:14Z |
| format | Article |
| id | doaj.art-44a1994a48664ec093702c75f7e8d597 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-18T00:07:14Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-44a1994a48664ec093702c75f7e8d5972022-12-21T21:27:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-11-011210.3389/fpsyt.2021.624993624993Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin LevelsJing Song Wang0Jing Lin Liu1Jun Zhang2Jun Tan3Ting Huang4Chun Xia Lu5Xi Yang Peng6Yin Guo7Lan Zheng8Key Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaHunan Judicial Police Vocational College, Changsha, ChinaCollege of Physical Education, Hunan International Economics University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaKey Laboratory of Physical Fitness and Sports Rehabilitation of the Hunan Province, College of Physical Education, Hunan Normal University, Changsha, ChinaPurpose: This study explored the association between peripheral blood oxytocin (OT) and social anxiety disorder (SAD) and cue-induced cravings in female heroin addicts. The effect of exercise on alleviation of SAD and OT levels was also explored.Methods: A total of 72 females with heroin dependence were assigned to three groups based on SAD severity. The three groups were Non-SAD control, SAD control, and SAD exercise groups. Subjects in the SAD exercise group underwent aerobic exercise and resistance training for 8 weeks (60 min/day, 5 days/week). Enzyme-linked immunosorbent assay analysis and Liebowitz Social Anxiety Scale (LSAS) scores were used to determine plasma OT concentration and SAD, respectively. Cue-induced craving was assessed using Visual Analog Scale (VAS) and Desires for Drug Questionnaire (DDQ). Mixed-effect analysis of variance and Pearson correlation analysis were used to explore the effect and correlation between different parameters.Results: OT levels in the SAD exercise group were significantly high after exercise (p < 0.01). LSAS, VAS, and DDQ (“Desire and Intention” and “Negative reinforcement”) scores in the SAD exercise group were significantly lower after exercise (p < 0.01). Plasma OT level was negatively correlated with LSAS score (r = −0.534, p < 0.001), VAS score (r = −0.609, p < 0.001), “Desire and Intention” score (r = −0.555, p < 0.001), and “Negative reinforcement” score (r = −0.332, p < 0.01) and positively correlated with the “control” score (r = 0.258, p < 0.05). LSAS was positively correlated with VAS score (r = 0.588, p < 0.001) and “Desire and Intention” score (r = 0.282, p < 0.05).Conclusions: The findings of the present study indicate that plasma OT is a potential peripheral biomarker for prediction of the severity of social anxiety in female heroin withdrawal patients. Aerobic exercise combined with resistance training plus incremental load for 8 weeks can increase plasma OT levels and significantly reduce severity of SAD and cue-induced cravings in female heroin addicts.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.624993/fullexerciseoxytocinSADVASDDQcraving |
| spellingShingle | Jing Song Wang Jing Lin Liu Jun Zhang Jun Tan Ting Huang Chun Xia Lu Xi Yang Peng Yin Guo Lan Zheng Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels Frontiers in Psychiatry exercise oxytocin SAD VAS DDQ craving |
| title | Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels |
| title_full | Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels |
| title_fullStr | Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels |
| title_full_unstemmed | Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels |
| title_short | Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels |
| title_sort | descended social anxiety disorder and craving in women heroin dependence through exercise alerts plasma oxytocin levels |
| topic | exercise oxytocin SAD VAS DDQ craving |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.624993/full |
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