Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014
Administration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive stra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2016-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/6/15-0376_article |
| _version_ | 1818036204047695872 |
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| author | Andrés Zorrilla-Vaca Jimmy J. Arevalo Kevin Escandón-Vargas Daniel Soltanifar Marek A. Mirski |
| author_facet | Andrés Zorrilla-Vaca Jimmy J. Arevalo Kevin Escandón-Vargas Daniel Soltanifar Marek A. Mirski |
| author_sort | Andrés Zorrilla-Vaca |
| collection | DOAJ |
| description | Administration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989–2014. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. There remains a lack of comprehensive information on the effectiveness of measures to prevent future outbreaks. |
| first_indexed | 2024-12-10T07:07:14Z |
| format | Article |
| id | doaj.art-44a1d5b146de44929ccf19aaef879444 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T07:07:14Z |
| publishDate | 2016-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-44a1d5b146de44929ccf19aaef8794442022-12-22T01:58:08ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-06-0122698199210.3201/eid2206.150376Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014Andrés Zorrilla-VacaJimmy J. ArevaloKevin Escandón-VargasDaniel SoltanifarMarek A. MirskiAdministration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989–2014. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. There remains a lack of comprehensive information on the effectiveness of measures to prevent future outbreaks.https://wwwnc.cdc.gov/eid/article/22/6/15-0376_articleanesthesiaPropofolcontaminationhospital infectionoutbreaksafety |
| spellingShingle | Andrés Zorrilla-Vaca Jimmy J. Arevalo Kevin Escandón-Vargas Daniel Soltanifar Marek A. Mirski Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 Emerging Infectious Diseases anesthesia Propofol contamination hospital infection outbreak safety |
| title | Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 |
| title_full | Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 |
| title_fullStr | Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 |
| title_full_unstemmed | Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 |
| title_short | Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 |
| title_sort | infectious disease risk associated with contaminated propofol anesthesia 1989 2014 |
| topic | anesthesia Propofol contamination hospital infection outbreak safety |
| url | https://wwwnc.cdc.gov/eid/article/22/6/15-0376_article |
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