Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes
Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that is primarily controlled by vaccination of susceptible animals and movement restrictions for animals and animal-derived products in South Africa. Vaccination using aluminium hydroxide gel-saponin (AS)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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AOSIS
2008-09-01
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| Series: | Onderstepoort Journal of Veterinary Research |
| Online Access: | https://ojvr.org/index.php/ojvr/article/view/84 |
| _version_ | 1828325051465728000 |
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| author | M. Cloete B. Dungu L.I. Van Staden N. Ismail-Cassim W. Vosloo |
| author_facet | M. Cloete B. Dungu L.I. Van Staden N. Ismail-Cassim W. Vosloo |
| author_sort | M. Cloete |
| collection | DOAJ |
| description | Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that is primarily controlled by vaccination of susceptible animals and movement restrictions for animals and animal-derived products in South Africa. Vaccination using aluminium hydroxide gel-saponin (AS) adjuvanted vaccines containing the South African Territories (SAT) serotypes has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone and in controlling outbreaks in the free zone. Various vaccine formulations containing antigens derived from the SAT serotypes were tested in cattle that were challenged 1 year later. Both the AS and ISA 206B vaccines adjuvanted with saponin protected cattle against virulent virus challenge. The oilbased ISA 206B-adjuvanted vaccine with and without stimulators was evaluated in a field trial and both elicited antibody responses that lasted for 1 year. Furthermore, the ISA 206 adjuvanted FMD vaccine protected groups of cattle against homologous virus challenge at very low payloads, while pigs vaccinated with an emergency ISA 206B-based FMD vaccine containing the SAT 1 vaccine strains were protected against the heterologous SAT 1 outbreak strain. |
| first_indexed | 2024-04-13T19:16:34Z |
| format | Article |
| id | doaj.art-44a340b8abcf436aa307b63cbd4aab28 |
| institution | Directory Open Access Journal |
| issn | 0030-2465 2219-0635 |
| language | English |
| last_indexed | 2024-04-13T19:16:34Z |
| publishDate | 2008-09-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Onderstepoort Journal of Veterinary Research |
| spelling | doaj.art-44a340b8abcf436aa307b63cbd4aab282022-12-22T02:33:39ZengAOSISOnderstepoort Journal of Veterinary Research0030-24652219-06352008-09-01751173110.4102/ojvr.v75i1.8474Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypesM. CloeteB. DunguL.I. Van StadenN. Ismail-CassimW. VoslooFoot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that is primarily controlled by vaccination of susceptible animals and movement restrictions for animals and animal-derived products in South Africa. Vaccination using aluminium hydroxide gel-saponin (AS) adjuvanted vaccines containing the South African Territories (SAT) serotypes has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone and in controlling outbreaks in the free zone. Various vaccine formulations containing antigens derived from the SAT serotypes were tested in cattle that were challenged 1 year later. Both the AS and ISA 206B vaccines adjuvanted with saponin protected cattle against virulent virus challenge. The oilbased ISA 206B-adjuvanted vaccine with and without stimulators was evaluated in a field trial and both elicited antibody responses that lasted for 1 year. Furthermore, the ISA 206 adjuvanted FMD vaccine protected groups of cattle against homologous virus challenge at very low payloads, while pigs vaccinated with an emergency ISA 206B-based FMD vaccine containing the SAT 1 vaccine strains were protected against the heterologous SAT 1 outbreak strain.https://ojvr.org/index.php/ojvr/article/view/84 |
| spellingShingle | M. Cloete B. Dungu L.I. Van Staden N. Ismail-Cassim W. Vosloo Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes Onderstepoort Journal of Veterinary Research |
| title | Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes |
| title_full | Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes |
| title_fullStr | Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes |
| title_full_unstemmed | Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes |
| title_short | Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes |
| title_sort | evaluation of different adjuvants for foot and mouth disease vaccine containing all the sat serotypes |
| url | https://ojvr.org/index.php/ojvr/article/view/84 |
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