Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid
The purpose of this study was to prepare the oleanolic acid–phospholipid complex (OA-PC) and then solidify it employing fumed silica by simple solvent evaporation technique to improve dissolution rate of oleanolic acid and oleanolic acid–phospholipid complex. The process of OA-PC was optimized and t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087615000598 |
| _version_ | 1818960957327540224 |
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| author | Xiaoxu Yang Qikun Jiang Ping Du Juanhang Zhao Tianhong Zhang |
| author_facet | Xiaoxu Yang Qikun Jiang Ping Du Juanhang Zhao Tianhong Zhang |
| author_sort | Xiaoxu Yang |
| collection | DOAJ |
| description | The purpose of this study was to prepare the oleanolic acid–phospholipid complex (OA-PC) and then solidify it employing fumed silica by simple solvent evaporation technique to improve dissolution rate of oleanolic acid and oleanolic acid–phospholipid complex. The process of OA-PC was optimized and the type and proportion of fumed silica were studied by dissolution text. The structures of the phospholipid complex and solidified powder were also characterized by differential scanning calorimetry, X-ray diffraction, and scanning electron microscope. In the dissolution tests, OA from solidified powder was further released compared with that from pure OA and OA-PC in different kinds of dissolution media. These results suggest that the method of preparing solidified powder of oleanolic acid–phospholipid complex is suitable for enhancing the dissolution rate of OA and OA-PC. |
| first_indexed | 2024-12-20T12:05:47Z |
| format | Article |
| id | doaj.art-44a464671e334f1d8ce03f7ffa2dcffc |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-20T12:05:47Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-44a464671e334f1d8ce03f7ffa2dcffc2022-12-21T19:41:23ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762016-04-0111224124710.1016/j.ajps.2015.07.002Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acidXiaoxu YangQikun JiangPing DuJuanhang ZhaoTianhong ZhangThe purpose of this study was to prepare the oleanolic acid–phospholipid complex (OA-PC) and then solidify it employing fumed silica by simple solvent evaporation technique to improve dissolution rate of oleanolic acid and oleanolic acid–phospholipid complex. The process of OA-PC was optimized and the type and proportion of fumed silica were studied by dissolution text. The structures of the phospholipid complex and solidified powder were also characterized by differential scanning calorimetry, X-ray diffraction, and scanning electron microscope. In the dissolution tests, OA from solidified powder was further released compared with that from pure OA and OA-PC in different kinds of dissolution media. These results suggest that the method of preparing solidified powder of oleanolic acid–phospholipid complex is suitable for enhancing the dissolution rate of OA and OA-PC.http://www.sciencedirect.com/science/article/pii/S1818087615000598Oleanolic acidPhospholipid complexFumed silicaDissolution |
| spellingShingle | Xiaoxu Yang Qikun Jiang Ping Du Juanhang Zhao Tianhong Zhang Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid Asian Journal of Pharmaceutical Sciences Oleanolic acid Phospholipid complex Fumed silica Dissolution |
| title | Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid |
| title_full | Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid |
| title_fullStr | Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid |
| title_full_unstemmed | Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid |
| title_short | Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid |
| title_sort | preparation and characterization of solidified oleanolic acid phospholipid complex aiming to improve the dissolution of oleanolic acid |
| topic | Oleanolic acid Phospholipid complex Fumed silica Dissolution |
| url | http://www.sciencedirect.com/science/article/pii/S1818087615000598 |
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