Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan
Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue.Methods: We conducted a population-based case-control...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00481/full |
| _version_ | 1818010488026431488 |
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| author | Kao-Chi Cheng Kao-Chi Cheng Kuan-Fu Liao Kuan-Fu Liao Kuan-Fu Liao Cheng-Li Lin Cheng-Li Lin Shih-Wei Lai Shih-Wei Lai |
| author_facet | Kao-Chi Cheng Kao-Chi Cheng Kuan-Fu Liao Kuan-Fu Liao Kuan-Fu Liao Cheng-Li Lin Cheng-Li Lin Shih-Wei Lai Shih-Wei Lai |
| author_sort | Kao-Chi Cheng |
| collection | DOAJ |
| description | Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue.Methods: We conducted a population-based case-control study to identify 9,422 subjects aged 20 years or older with newly diagnosed pulmonary TB in 2000–2013 as test cases. We then randomly selected 9,422 subjects aged 20 years or older without pulmonary TB as controls. Both cases and controls were matched in terms of sex, age, and comorbidities. Use of PPIs were defined as subjects who had had at least one prescription for these medications before the index date. No use was defined as subjects who had never had a prescription for PPIs before the index date. The odds ratio (OR) and 95% confidence interval (CI) for pulmonary TB associated with PPI use was estimated using the logistic regression model.Results: The OR of pulmonary TB was 1.31 for subjects who had used PPIs (95% CI 1.22, 1.41) compared with those with no use of the medications. Sub-analysis revealed the OR of pulmonary TB in subjects using PPI per increasing microgram was 1.25 (95% CI 1.19, 1.30).Conclusions: PPI use is associated with a 1.3-fold increase in odds of developing pulmonary TB in Taiwan. There is a dose-related response between PPI use and pulmonary TB. |
| first_indexed | 2024-04-14T05:55:59Z |
| format | Article |
| id | doaj.art-44a75480ec924f3a847d3f9c8dea3ebb |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-14T05:55:59Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-44a75480ec924f3a847d3f9c8dea3ebb2022-12-22T02:08:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-07-01810.3389/fphar.2017.00481281401Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in TaiwanKao-Chi Cheng0Kao-Chi Cheng1Kuan-Fu Liao2Kuan-Fu Liao3Kuan-Fu Liao4Cheng-Li Lin5Cheng-Li Lin6Shih-Wei Lai7Shih-Wei Lai8College of Medicine, China Medical UniversityTaichung, TaiwanDepartment of Family Medicine, China Medical University HospitalTaichung, TaiwanDepartment of Internal Medicine, Taichung Tzu Chi General HospitalTaichung, TaiwanCollege of Medicine, Tzu Chi UniversityHualien, TaiwanGraduate Institute of Integrated Medicine, China Medical UniversityTaichung, TaiwanCollege of Medicine, China Medical UniversityTaichung, TaiwanManagement Office for Health Data, China Medical University HospitalTaichung, TaiwanCollege of Medicine, China Medical UniversityTaichung, TaiwanDepartment of Family Medicine, China Medical University HospitalTaichung, TaiwanBackground and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue.Methods: We conducted a population-based case-control study to identify 9,422 subjects aged 20 years or older with newly diagnosed pulmonary TB in 2000–2013 as test cases. We then randomly selected 9,422 subjects aged 20 years or older without pulmonary TB as controls. Both cases and controls were matched in terms of sex, age, and comorbidities. Use of PPIs were defined as subjects who had had at least one prescription for these medications before the index date. No use was defined as subjects who had never had a prescription for PPIs before the index date. The odds ratio (OR) and 95% confidence interval (CI) for pulmonary TB associated with PPI use was estimated using the logistic regression model.Results: The OR of pulmonary TB was 1.31 for subjects who had used PPIs (95% CI 1.22, 1.41) compared with those with no use of the medications. Sub-analysis revealed the OR of pulmonary TB in subjects using PPI per increasing microgram was 1.25 (95% CI 1.19, 1.30).Conclusions: PPI use is associated with a 1.3-fold increase in odds of developing pulmonary TB in Taiwan. There is a dose-related response between PPI use and pulmonary TB.http://journal.frontiersin.org/article/10.3389/fphar.2017.00481/fullpulmonary tuberculosisproton pump inhibitorsTaiwan National Health Insurance Program |
| spellingShingle | Kao-Chi Cheng Kao-Chi Cheng Kuan-Fu Liao Kuan-Fu Liao Kuan-Fu Liao Cheng-Li Lin Cheng-Li Lin Shih-Wei Lai Shih-Wei Lai Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan Frontiers in Pharmacology pulmonary tuberculosis proton pump inhibitors Taiwan National Health Insurance Program |
| title | Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan |
| title_full | Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan |
| title_fullStr | Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan |
| title_full_unstemmed | Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan |
| title_short | Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan |
| title_sort | correlation of proton pump inhibitors with pulmonary tuberculosis a case control study in taiwan |
| topic | pulmonary tuberculosis proton pump inhibitors Taiwan National Health Insurance Program |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00481/full |
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