Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants
BackgroundSilicone implants have been used since the 1960s for aesthetic purposes and breast reconstructions. During this period, many women have reported up to 40 similar symptoms, including fatigue, the emergence of autoimmune diseases, Raynaud Phenomenon, arthritis, arthralgias, and hair loss, am...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Global Women's Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgwh.2022.730276/full |
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| author | Jessica C. R. Mustafá Eduardo de Faria Castro Fleury Henry B. P. M. Dijkman |
| author_facet | Jessica C. R. Mustafá Eduardo de Faria Castro Fleury Henry B. P. M. Dijkman |
| author_sort | Jessica C. R. Mustafá |
| collection | DOAJ |
| description | BackgroundSilicone implants have been used since the 1960s for aesthetic purposes and breast reconstructions. During this period, many women have reported up to 40 similar symptoms, including fatigue, the emergence of autoimmune diseases, Raynaud Phenomenon, arthritis, arthralgias, and hair loss, among others. However, most of the time, these symptoms are neglected by doctors across different specialties and are most often considered a psychosomatic disease. Since 2017, many women suffering from the same complaints have formed social media groups to report their histories and subsequently describe the disease as Breast Implant Illness (BII). The phenomenon of gel bleed and silicone toxicity is known and accepted in literature, but silicone migration into the extracapsular space is still poorly demonstrated, due to the difficulty of monitoring its particles and access to patient data.MethodsThis work demonstrated the presence of silicone through pathological examination in post-explant breast capsules and in the synovial tissue of the right wrist, detected with special Modified Oil Red O (MORO) staining in a patient with a history of BII. The pathological results were compared to the breast MRI imaging files.ResultsThe MRI images show the permeability change of the implant shell diagnosed as a water-droplet signal. It was also possible to diagnose the gel bleeding as the silicone-induced granuloma of breast implant capsule (SIGBIC) in both implants. Silicone gel bleed and migration of silicone were detected with MORO staining in and outside the capsule and in the synovial tissue of the right wrist.ConclusionIn this case study, we showed that silicone migration is possible via cohesive silicone gel breast implant leakage. The accumulation of silicone in the synovial tissue of the right wrist suggests local silicone toxicity and defects. |
| first_indexed | 2024-12-10T09:22:07Z |
| format | Article |
| id | doaj.art-44a7fdec64f545e58a5cedbf89c81e0c |
| institution | Directory Open Access Journal |
| issn | 2673-5059 |
| language | English |
| last_indexed | 2024-12-10T09:22:07Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Global Women's Health |
| spelling | doaj.art-44a7fdec64f545e58a5cedbf89c81e0c2022-12-22T01:54:40ZengFrontiers Media S.A.Frontiers in Global Women's Health2673-50592022-04-01310.3389/fgwh.2022.730276730276Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast ImplantsJessica C. R. Mustafá0Eduardo de Faria Castro Fleury1Henry B. P. M. Dijkman2UEMS Universidade Do Estado Do Mato Grosso Do Sul, Campo Grande, BrazilCentro Universitário São Camilo, Curso de Medicina, São Paulo, BrazilInstitute of Applied Biosciences and Chemistry, HAN University of Applied Sciences, Nijmegen, NetherlandsBackgroundSilicone implants have been used since the 1960s for aesthetic purposes and breast reconstructions. During this period, many women have reported up to 40 similar symptoms, including fatigue, the emergence of autoimmune diseases, Raynaud Phenomenon, arthritis, arthralgias, and hair loss, among others. However, most of the time, these symptoms are neglected by doctors across different specialties and are most often considered a psychosomatic disease. Since 2017, many women suffering from the same complaints have formed social media groups to report their histories and subsequently describe the disease as Breast Implant Illness (BII). The phenomenon of gel bleed and silicone toxicity is known and accepted in literature, but silicone migration into the extracapsular space is still poorly demonstrated, due to the difficulty of monitoring its particles and access to patient data.MethodsThis work demonstrated the presence of silicone through pathological examination in post-explant breast capsules and in the synovial tissue of the right wrist, detected with special Modified Oil Red O (MORO) staining in a patient with a history of BII. The pathological results were compared to the breast MRI imaging files.ResultsThe MRI images show the permeability change of the implant shell diagnosed as a water-droplet signal. It was also possible to diagnose the gel bleeding as the silicone-induced granuloma of breast implant capsule (SIGBIC) in both implants. Silicone gel bleed and migration of silicone were detected with MORO staining in and outside the capsule and in the synovial tissue of the right wrist.ConclusionIn this case study, we showed that silicone migration is possible via cohesive silicone gel breast implant leakage. The accumulation of silicone in the synovial tissue of the right wrist suggests local silicone toxicity and defects.https://www.frontiersin.org/articles/10.3389/fgwh.2022.730276/fullsilicone breast implantsilicone gel bleedsilicone migrationhistologynon-cohesive silicone gelcohesive silicone gel |
| spellingShingle | Jessica C. R. Mustafá Eduardo de Faria Castro Fleury Henry B. P. M. Dijkman Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants Frontiers in Global Women's Health silicone breast implant silicone gel bleed silicone migration histology non-cohesive silicone gel cohesive silicone gel |
| title | Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants |
| title_full | Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants |
| title_fullStr | Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants |
| title_full_unstemmed | Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants |
| title_short | Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants |
| title_sort | case report evidence of migratory silicone particles arising from cohesive silicone breast implants |
| topic | silicone breast implant silicone gel bleed silicone migration histology non-cohesive silicone gel cohesive silicone gel |
| url | https://www.frontiersin.org/articles/10.3389/fgwh.2022.730276/full |
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