Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report
Rheumatoid arthritis (RA) is an autoimmune disease affecting about 1% of people, with the highest incidence between 40 and 70 years. Methotrexate is an anti-folate analogue that has good efficacy and safety in the treatment of RA. Methotrexate (MTX) and non-steroidal anti inflammatory drugs are of...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6244/14221_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(P)_PF2(PAG).pdf |
| _version_ | 1818415042945613824 |
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| author | P.R Rachana HV Anuradha Reddy Mounika |
| author_facet | P.R Rachana HV Anuradha Reddy Mounika |
| author_sort | P.R Rachana |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an autoimmune disease affecting about 1% of people, with the highest incidence between 40 and 70 years.
Methotrexate is an anti-folate analogue that has good efficacy and safety in the treatment of RA. Methotrexate (MTX) and non-steroidal
anti inflammatory drugs are often concomitantly administered in clinical practice for the treatment of RA. In this case report, a 57-yearold female was treated with oral methotrexate 7.5 mg per week for a diagnosed case of RA. Since her pain persisted after completing
six weeks of treatment with methotrexate, oral etoricoxib 60 mg once daily was added to the treatment regimen. Six weeks later, the
patient complained of oral ulcerations and blisters on all fours limbs and trunk. The patient was re-evaluated and was diagnosed with
Stevens-Johnson syndrome-Toxic epidermal necrolysis (SJS-TEN) overlap. This case highlights the possible pharmacokinetic interaction
between methotrexate and etoricoxib that has a significant clinical implication. |
| first_indexed | 2024-12-14T11:28:43Z |
| format | Article |
| id | doaj.art-44a8a8304ee9444ba077866d8a5d8f84 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T11:28:43Z |
| publishDate | 2015-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-44a8a8304ee9444ba077866d8a5d8f842022-12-21T23:03:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-07-0197FD01FD0310.7860/JCDR/2015/14221.6244Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case ReportP.R Rachana0HV Anuradha1Reddy Mounika2Post Graduate, Department of Pharmaology, M.S Ramaiah Medical College, Bangalore, India.Associate Professor, Department of Pharmacology, M.S Ramaiah Medical College, Bangalore, India.Post Graduate, Department of Dermatology, M.S Ramaiah Medical College, Bangalore, India.Rheumatoid arthritis (RA) is an autoimmune disease affecting about 1% of people, with the highest incidence between 40 and 70 years. Methotrexate is an anti-folate analogue that has good efficacy and safety in the treatment of RA. Methotrexate (MTX) and non-steroidal anti inflammatory drugs are often concomitantly administered in clinical practice for the treatment of RA. In this case report, a 57-yearold female was treated with oral methotrexate 7.5 mg per week for a diagnosed case of RA. Since her pain persisted after completing six weeks of treatment with methotrexate, oral etoricoxib 60 mg once daily was added to the treatment regimen. Six weeks later, the patient complained of oral ulcerations and blisters on all fours limbs and trunk. The patient was re-evaluated and was diagnosed with Stevens-Johnson syndrome-Toxic epidermal necrolysis (SJS-TEN) overlap. This case highlights the possible pharmacokinetic interaction between methotrexate and etoricoxib that has a significant clinical implication.https://jcdr.net/articles/PDF/6244/14221_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(P)_PF2(PAG).pdfdrug interactionnon-steroidal anti-inflammatory drugsrheumatoid arthritis |
| spellingShingle | P.R Rachana HV Anuradha Reddy Mounika Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report Journal of Clinical and Diagnostic Research drug interaction non-steroidal anti-inflammatory drugs rheumatoid arthritis |
| title | Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report |
| title_full | Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report |
| title_fullStr | Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report |
| title_full_unstemmed | Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report |
| title_short | Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap Secondary to Interaction Between Methotrexate and Etoricoxib: A Case Report |
| title_sort | stevens johnson syndrome toxic epidermal necrolysis overlap secondary to interaction between methotrexate and etoricoxib a case report |
| topic | drug interaction non-steroidal anti-inflammatory drugs rheumatoid arthritis |
| url | https://jcdr.net/articles/PDF/6244/14221_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(P)_PF2(PAG).pdf |
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