CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
Background: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospecti...
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/2/341 |
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| author | Yunha Nam Chang-Min Choi Young Soo Park HyunA Jung Hee Sang Hwang Jae Cheol Lee Jung Wook Lee Jung Eun Lee Jung Hee Kang Byung Hun Jung Wonjun Ji |
| author_facet | Yunha Nam Chang-Min Choi Young Soo Park HyunA Jung Hee Sang Hwang Jae Cheol Lee Jung Wook Lee Jung Eun Lee Jung Hee Kang Byung Hun Jung Wonjun Ji |
| author_sort | Yunha Nam |
| collection | DOAJ |
| description | Background: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospective study, we collected medical records of patients with NSCLC and matched tissue microarray blocks from surgical specimens. Semiquantitative immunohistochemistry was performed for measuring the expression level of fibroblast activation protein-alpha (FAP-α), Jagged-1 (JAG1), and CUB-domain-containing protein 1 (CDCP1). Results: A total of 453 patients who underwent complete resection between January 2011 and February 2012 were enrolled; 55.2% patients had stage I NSCLC, and 31.1% presented squamous cell carcinoma. Disease stage was a significant risk factor for recurrence and death, and age ≥ 65 years and male sex were associated with poor overall survival. FAP-a and JaG1 were not related to survivals, while CDCP1-expressing patients exhibited poor disease-free and overall survival. Moreover, CDCP1 expression in stage I NSCLC was significantly associated with recurrence. Conclusions: Old age, male sex, and high pathological stage were poor prognostic factors in patients with NSCLC who underwent surgical resection. Furthermore, CDCP1 expression could serve as a biomarker for poor prognosis in stage I NSCLC. |
| first_indexed | 2024-03-10T01:14:01Z |
| format | Article |
| id | doaj.art-44a97fd3903c4bb79f47286daf3ebac7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:14:01Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-44a97fd3903c4bb79f47286daf3ebac72023-11-23T14:12:22ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111234110.3390/jcm11020341CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung CancerYunha Nam0Chang-Min Choi1Young Soo Park2HyunA Jung3Hee Sang Hwang4Jae Cheol Lee5Jung Wook Lee6Jung Eun Lee7Jung Hee Kang8Byung Hun Jung9Wonjun Ji10Asan Medical Center, Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Pathology, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Pathology, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Oncology, University of Ulsan College of Medicine, Seoul 05505, KoreaTherapeutic Antibody R&D Center, Theranotics Co., Ltd., Seoul 05842, KoreaTherapeutic Antibody R&D Center, Theranotics Co., Ltd., Seoul 05842, KoreaTherapeutic Antibody R&D Center, Theranotics Co., Ltd., Seoul 05842, KoreaTherapeutic Antibody R&D Center, Theranotics Co., Ltd., Seoul 05842, KoreaAsan Medical Center, Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaBackground: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospective study, we collected medical records of patients with NSCLC and matched tissue microarray blocks from surgical specimens. Semiquantitative immunohistochemistry was performed for measuring the expression level of fibroblast activation protein-alpha (FAP-α), Jagged-1 (JAG1), and CUB-domain-containing protein 1 (CDCP1). Results: A total of 453 patients who underwent complete resection between January 2011 and February 2012 were enrolled; 55.2% patients had stage I NSCLC, and 31.1% presented squamous cell carcinoma. Disease stage was a significant risk factor for recurrence and death, and age ≥ 65 years and male sex were associated with poor overall survival. FAP-a and JaG1 were not related to survivals, while CDCP1-expressing patients exhibited poor disease-free and overall survival. Moreover, CDCP1 expression in stage I NSCLC was significantly associated with recurrence. Conclusions: Old age, male sex, and high pathological stage were poor prognostic factors in patients with NSCLC who underwent surgical resection. Furthermore, CDCP1 expression could serve as a biomarker for poor prognosis in stage I NSCLC.https://www.mdpi.com/2077-0383/11/2/341lung cancernon-small-cell lung cancersurgical resectionCDCP1biomarkerprognosis |
| spellingShingle | Yunha Nam Chang-Min Choi Young Soo Park HyunA Jung Hee Sang Hwang Jae Cheol Lee Jung Wook Lee Jung Eun Lee Jung Hee Kang Byung Hun Jung Wonjun Ji CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer Journal of Clinical Medicine lung cancer non-small-cell lung cancer surgical resection CDCP1 biomarker prognosis |
| title | CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer |
| title_full | CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer |
| title_fullStr | CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer |
| title_full_unstemmed | CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer |
| title_short | CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer |
| title_sort | cdcp1 expression is a potential biomarker of poor prognosis in resected stage i non small cell lung cancer |
| topic | lung cancer non-small-cell lung cancer surgical resection CDCP1 biomarker prognosis |
| url | https://www.mdpi.com/2077-0383/11/2/341 |
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