Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

Abstract Background Previous studies reported that emodin extracted from Rheum palmatum L. exerts antiproliferation and antimetastatic effects in a variety of human cancer types. However, the role of emodin in hepatocellular carcinoma (HCC) remain unknown. Methods EdU and colony formation assays wer...

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Bibliographic Details
Main Authors: Binyu Qin, Zhili Zeng, Jianliang Xu, Jing Shangwen, Zeng Jie Ye, Shutang Wang, Yanheng Wu, Gongfeng Peng, Qi Wang, Wenyi Gu, Ying Tang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Cancer
Subjects:
Emodin
Hepatocellular carcinoma
Autophagy
Epithelial-mesenchymal transition
PI3K/AKT/mTOR
Wnt/β-catenin
Online Access:https://doi.org/10.1186/s12885-022-09684-0

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