Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil
The emergence and rapid spread of the SARS-CoV-2 Gamma variant in Brazil have raised concerns about SARS-CoV-2 vaccines’ neutralizing capacity and viral load impact. Our study aimed to assess the influence of the CoviShield and CoronaVac vaccines on the Ct-N2 value in the healthcare organization’s s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | COVID |
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| Online Access: | https://www.mdpi.com/2673-8112/3/11/112 |
| _version_ | 1797459659703975936 |
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| author | Jesús Enrique Patiño Escarcina Felipe de Jesus Souza Ana Keila Carvalho Vieira Da Silva Keile Kemyly Assis Da Silva Ruan Barbosa Souza Saulo Reis Nery Santos Eduardo M. Netto |
| author_facet | Jesús Enrique Patiño Escarcina Felipe de Jesus Souza Ana Keila Carvalho Vieira Da Silva Keile Kemyly Assis Da Silva Ruan Barbosa Souza Saulo Reis Nery Santos Eduardo M. Netto |
| author_sort | Jesús Enrique Patiño Escarcina |
| collection | DOAJ |
| description | The emergence and rapid spread of the SARS-CoV-2 Gamma variant in Brazil have raised concerns about SARS-CoV-2 vaccines’ neutralizing capacity and viral load impact. Our study aimed to assess the influence of the CoviShield and CoronaVac vaccines on the Ct-N2 value in the healthcare organization’s staff who experienced primary SARS-CoV-2 infection. We examined sixty-three COVID-19 cases reported in the first half of 2021 and identified similar clinical and laboratory characteristics among individuals, regardless of the vaccine they received. Surprisingly, our observations revealed that both CoviShield and CoronaVac vaccines had no impact on viral load or the development and severity of symptoms. These findings suggest a potential reduction in neutralizing response and indicate the need to consider the incorporation of other SARS-CoV-2 vaccines and maintain additional containment measures against SARS-CoV-2, as they remain imperative despite vaccination efforts. |
| first_indexed | 2024-03-09T16:54:35Z |
| format | Article |
| id | doaj.art-44a9b7ccb44b4142aa05d3c1d0aaaf77 |
| institution | Directory Open Access Journal |
| issn | 2673-8112 |
| language | English |
| last_indexed | 2024-03-09T16:54:35Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | COVID |
| spelling | doaj.art-44a9b7ccb44b4142aa05d3c1d0aaaf772023-11-24T14:36:33ZengMDPI AGCOVID2673-81122023-10-013111639164710.3390/covid3110112Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, BrazilJesús Enrique Patiño Escarcina0Felipe de Jesus Souza1Ana Keila Carvalho Vieira Da Silva2Keile Kemyly Assis Da Silva3Ruan Barbosa Souza4Saulo Reis Nery Santos5Eduardo M. Netto6José Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilJosé Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, BrazilThe emergence and rapid spread of the SARS-CoV-2 Gamma variant in Brazil have raised concerns about SARS-CoV-2 vaccines’ neutralizing capacity and viral load impact. Our study aimed to assess the influence of the CoviShield and CoronaVac vaccines on the Ct-N2 value in the healthcare organization’s staff who experienced primary SARS-CoV-2 infection. We examined sixty-three COVID-19 cases reported in the first half of 2021 and identified similar clinical and laboratory characteristics among individuals, regardless of the vaccine they received. Surprisingly, our observations revealed that both CoviShield and CoronaVac vaccines had no impact on viral load or the development and severity of symptoms. These findings suggest a potential reduction in neutralizing response and indicate the need to consider the incorporation of other SARS-CoV-2 vaccines and maintain additional containment measures against SARS-CoV-2, as they remain imperative despite vaccination efforts.https://www.mdpi.com/2673-8112/3/11/112viral loadSARS-CoV-2vaccines |
| spellingShingle | Jesús Enrique Patiño Escarcina Felipe de Jesus Souza Ana Keila Carvalho Vieira Da Silva Keile Kemyly Assis Da Silva Ruan Barbosa Souza Saulo Reis Nery Santos Eduardo M. Netto Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil COVID viral load SARS-CoV-2 vaccines |
| title | Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil |
| title_full | Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil |
| title_fullStr | Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil |
| title_full_unstemmed | Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil |
| title_short | Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil |
| title_sort | evaluation of coronavac and covishield vaccines on sars cov 2 infection in healthcare workers in salvador brazil |
| topic | viral load SARS-CoV-2 vaccines |
| url | https://www.mdpi.com/2673-8112/3/11/112 |
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