Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review
After haematopoietic stem cell transplantation and a history of GVHD, the risk of developing secondary malignancies, including oral cancer, is higher. This risk increases with time post-transplantation; therefore, pediatric patients undergoing HSCT, who have long-term survival chances, are in a high...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5775 |
| _version_ | 1797463539795886080 |
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| author | Tiziana Cantile Noemi Coppola Federica Canfora Daniela Adamo Elvira Ruoppo Michele Davide Mignogna Stefania Leuci |
| author_facet | Tiziana Cantile Noemi Coppola Federica Canfora Daniela Adamo Elvira Ruoppo Michele Davide Mignogna Stefania Leuci |
| author_sort | Tiziana Cantile |
| collection | DOAJ |
| description | After haematopoietic stem cell transplantation and a history of GVHD, the risk of developing secondary malignancies, including oral cancer, is higher. This risk increases with time post-transplantation; therefore, pediatric patients undergoing HSCT, who have long-term survival chances, are in a high-risk category. The aim of this review is to provide data on HSCT, GVHD, clinical manifestations, histological features and treatment of oral cancer, and outcomes in HSCT pediatric patients, affected by oral GVHD, who have been developed OSCC. Descriptive statistics were used to validate data. Fifteen studies on a total of 33 patients were selected. Data on oral cancer showed that the tongue was the most frequently involved site (13 pts; 39.39%), followed by the floor of the mouth (4 pts; 12.12%), and buccal mucosa (4 pts; 12.12%). Oral squamous cell carcinoma was the histological feature reported. There were 19 (57.58%) deaths occurring between 2 and 46.5 months after OC diagnosis. Eleven patients survived with a median follow-up of 34 months. Considering the high risk of developing oral cancer, a conventional oral examination every 6 months is recommended for HSCT pediatric patients who have developed GVHD. |
| first_indexed | 2024-03-09T17:52:10Z |
| format | Article |
| id | doaj.art-44ac34fb4c854b82a00142379abb5e26 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:52:10Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-44ac34fb4c854b82a00142379abb5e262023-11-24T10:38:27ZengMDPI AGCancers2072-66942022-11-011423577510.3390/cancers14235775Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive ReviewTiziana Cantile0Noemi Coppola1Federica Canfora2Daniela Adamo3Elvira Ruoppo4Michele Davide Mignogna5Stefania Leuci6Oral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyOral Medicine Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, ItalyAfter haematopoietic stem cell transplantation and a history of GVHD, the risk of developing secondary malignancies, including oral cancer, is higher. This risk increases with time post-transplantation; therefore, pediatric patients undergoing HSCT, who have long-term survival chances, are in a high-risk category. The aim of this review is to provide data on HSCT, GVHD, clinical manifestations, histological features and treatment of oral cancer, and outcomes in HSCT pediatric patients, affected by oral GVHD, who have been developed OSCC. Descriptive statistics were used to validate data. Fifteen studies on a total of 33 patients were selected. Data on oral cancer showed that the tongue was the most frequently involved site (13 pts; 39.39%), followed by the floor of the mouth (4 pts; 12.12%), and buccal mucosa (4 pts; 12.12%). Oral squamous cell carcinoma was the histological feature reported. There were 19 (57.58%) deaths occurring between 2 and 46.5 months after OC diagnosis. Eleven patients survived with a median follow-up of 34 months. Considering the high risk of developing oral cancer, a conventional oral examination every 6 months is recommended for HSCT pediatric patients who have developed GVHD.https://www.mdpi.com/2072-6694/14/23/5775pediatric oncologyhematopoietic stem cell transplantationHSCTGVHDOSCCoral cancer |
| spellingShingle | Tiziana Cantile Noemi Coppola Federica Canfora Daniela Adamo Elvira Ruoppo Michele Davide Mignogna Stefania Leuci Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review Cancers pediatric oncology hematopoietic stem cell transplantation HSCT GVHD OSCC oral cancer |
| title | Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review |
| title_full | Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review |
| title_fullStr | Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review |
| title_full_unstemmed | Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review |
| title_short | Oral Cancer in HSCT Pediatric Patients Arising on GVHD: A Comprehensive Review |
| title_sort | oral cancer in hsct pediatric patients arising on gvhd a comprehensive review |
| topic | pediatric oncology hematopoietic stem cell transplantation HSCT GVHD OSCC oral cancer |
| url | https://www.mdpi.com/2072-6694/14/23/5775 |
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