Endothelial Activation: The Ang/Tie Axis in Sepsis
Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mecha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00838/full |
| _version_ | 1818007716174495744 |
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| author | Aleksandra Leligdowicz Melissa Richard-Greenblatt Julie Wright Valerie M. Crowley Kevin C. Kain |
| author_facet | Aleksandra Leligdowicz Melissa Richard-Greenblatt Julie Wright Valerie M. Crowley Kevin C. Kain |
| author_sort | Aleksandra Leligdowicz |
| collection | DOAJ |
| description | Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mechanism of injury that contributes to the morbidity and mortality associated with the syndrome. Perturbations to the angiopoietin (Ang)/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis. In this review, we summarize how the Ang/Tie2 pathway is implicated in sepsis and describe its prognostic as well as therapeutic utility in life-threatening infections. |
| first_indexed | 2024-04-14T05:19:20Z |
| format | Article |
| id | doaj.art-44acc7c3a37840fa89abacc1fadf2164 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T05:19:20Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-44acc7c3a37840fa89abacc1fadf21642022-12-22T02:10:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-04-01910.3389/fimmu.2018.00838337082Endothelial Activation: The Ang/Tie Axis in SepsisAleksandra LeligdowiczMelissa Richard-GreenblattJulie WrightValerie M. CrowleyKevin C. KainSepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mechanism of injury that contributes to the morbidity and mortality associated with the syndrome. Perturbations to the angiopoietin (Ang)/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis. In this review, we summarize how the Ang/Tie2 pathway is implicated in sepsis and describe its prognostic as well as therapeutic utility in life-threatening infections.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00838/fullendothelial dysfunctionTie2 receptorangiopoietinssepsismalariacritical care |
| spellingShingle | Aleksandra Leligdowicz Melissa Richard-Greenblatt Julie Wright Valerie M. Crowley Kevin C. Kain Endothelial Activation: The Ang/Tie Axis in Sepsis Frontiers in Immunology endothelial dysfunction Tie2 receptor angiopoietins sepsis malaria critical care |
| title | Endothelial Activation: The Ang/Tie Axis in Sepsis |
| title_full | Endothelial Activation: The Ang/Tie Axis in Sepsis |
| title_fullStr | Endothelial Activation: The Ang/Tie Axis in Sepsis |
| title_full_unstemmed | Endothelial Activation: The Ang/Tie Axis in Sepsis |
| title_short | Endothelial Activation: The Ang/Tie Axis in Sepsis |
| title_sort | endothelial activation the ang tie axis in sepsis |
| topic | endothelial dysfunction Tie2 receptor angiopoietins sepsis malaria critical care |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00838/full |
| work_keys_str_mv | AT aleksandraleligdowicz endothelialactivationtheangtieaxisinsepsis AT melissarichardgreenblatt endothelialactivationtheangtieaxisinsepsis AT juliewright endothelialactivationtheangtieaxisinsepsis AT valeriemcrowley endothelialactivationtheangtieaxisinsepsis AT kevinckain endothelialactivationtheangtieaxisinsepsis |