An adipokine feedback regulating diurnal food intake rhythms in mice
Endogenous circadian clocks have evolved to anticipate 24 hr rhythms in environmental demands. Recent studies suggest that circadian rhythm disruption is a major risk factor for the development of metabolic disorders in humans. Conversely, alterations in energy state can disrupt circadian rhythms of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/55388 |
| _version_ | 1828271415990681600 |
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| author | Anthony H Tsang Christiane E Koch Jana-Thabea Kiehn Cosima X Schmidt Henrik Oster |
| author_facet | Anthony H Tsang Christiane E Koch Jana-Thabea Kiehn Cosima X Schmidt Henrik Oster |
| author_sort | Anthony H Tsang |
| collection | DOAJ |
| description | Endogenous circadian clocks have evolved to anticipate 24 hr rhythms in environmental demands. Recent studies suggest that circadian rhythm disruption is a major risk factor for the development of metabolic disorders in humans. Conversely, alterations in energy state can disrupt circadian rhythms of behavior and physiology, creating a vicious circle of metabolic dysfunction. How peripheral energy state affects diurnal food intake, however, is still poorly understood. We here show that the adipokine adiponectin (ADIPOQ) regulates diurnal feeding rhythms through clocks in energy regulatory centers of the mediobasal hypothalamus (MBH). Adipoq-deficient mice show increased rest phase food intake associated with disrupted transcript rhythms of clock and appetite-regulating genes in the MBH. ADIPOQ regulates MBH clocks via AdipoR1-mediated upregulation of the core clock gene Bmal1. BMAL1, in turn, controls expression of orexigenic neuropeptide expression in the MBH. Together, these data reveal a systemic metabolic circuit to regulate central circadian clocks and energy intake. |
| first_indexed | 2024-04-13T05:53:05Z |
| format | Article |
| id | doaj.art-44ae96b87447493ea0e39e882db4ff91 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-13T05:53:05Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-44ae96b87447493ea0e39e882db4ff912022-12-22T02:59:43ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.55388An adipokine feedback regulating diurnal food intake rhythms in miceAnthony H Tsang0Christiane E Koch1Jana-Thabea Kiehn2Cosima X Schmidt3Henrik Oster4https://orcid.org/0000-0002-1414-7068Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany; Institute of Neurobiology, University of Lübeck, Lübeck, GermanyInstitute of Neurobiology, University of Lübeck, Lübeck, GermanyInstitute of Neurobiology, University of Lübeck, Lübeck, GermanyInstitute of Neurobiology, University of Lübeck, Lübeck, GermanyCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany; Institute of Neurobiology, University of Lübeck, Lübeck, GermanyEndogenous circadian clocks have evolved to anticipate 24 hr rhythms in environmental demands. Recent studies suggest that circadian rhythm disruption is a major risk factor for the development of metabolic disorders in humans. Conversely, alterations in energy state can disrupt circadian rhythms of behavior and physiology, creating a vicious circle of metabolic dysfunction. How peripheral energy state affects diurnal food intake, however, is still poorly understood. We here show that the adipokine adiponectin (ADIPOQ) regulates diurnal feeding rhythms through clocks in energy regulatory centers of the mediobasal hypothalamus (MBH). Adipoq-deficient mice show increased rest phase food intake associated with disrupted transcript rhythms of clock and appetite-regulating genes in the MBH. ADIPOQ regulates MBH clocks via AdipoR1-mediated upregulation of the core clock gene Bmal1. BMAL1, in turn, controls expression of orexigenic neuropeptide expression in the MBH. Together, these data reveal a systemic metabolic circuit to regulate central circadian clocks and energy intake.https://elifesciences.org/articles/55388circadian clockadiponectinfood intakehypothalamus |
| spellingShingle | Anthony H Tsang Christiane E Koch Jana-Thabea Kiehn Cosima X Schmidt Henrik Oster An adipokine feedback regulating diurnal food intake rhythms in mice eLife circadian clock adiponectin food intake hypothalamus |
| title | An adipokine feedback regulating diurnal food intake rhythms in mice |
| title_full | An adipokine feedback regulating diurnal food intake rhythms in mice |
| title_fullStr | An adipokine feedback regulating diurnal food intake rhythms in mice |
| title_full_unstemmed | An adipokine feedback regulating diurnal food intake rhythms in mice |
| title_short | An adipokine feedback regulating diurnal food intake rhythms in mice |
| title_sort | adipokine feedback regulating diurnal food intake rhythms in mice |
| topic | circadian clock adiponectin food intake hypothalamus |
| url | https://elifesciences.org/articles/55388 |
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