Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki
Tatsushi Igaki is currently based at the Kyoto University Graduate School of Biostudies, where he leads a research group dedicated to using Drosophila genetics to build a picture of the cell-cell communications underlying the establishment and maintenance of multicellular systems. His work has provi...
| Format: | Article |
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| Language: | English |
| Published: |
The Company of Biologists
2015-12-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/8/12/1491 |
| _version_ | 1818912842750885888 |
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| collection | DOAJ |
| description | Tatsushi Igaki is currently based at the Kyoto University Graduate School of Biostudies, where he leads a research group dedicated to using Drosophila genetics to build a picture of the cell-cell communications underlying the establishment and maintenance of multicellular systems. His work has provided insight into the molecular bases of cell competition in the context of development and tumorigenesis, including the landmark discovery that oncogenic cells communicate with normal cells in the tumor microenvironment to induce tumor progression in a non-autonomous fashion. In this interview, he describes his career path, highlighting the shift in his research focus from the basic principles of apoptosis to clonal evolution in cancer, and also explains why Drosophila provides a powerful model system for studying cancer biology. |
| first_indexed | 2024-12-19T23:21:01Z |
| format | Article |
| id | doaj.art-44af3f57aef14a7687fe7edc3085c4f6 |
| institution | Directory Open Access Journal |
| issn | 1754-8411 1754-8403 |
| language | English |
| last_indexed | 2024-12-19T23:21:01Z |
| publishDate | 2015-12-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-44af3f57aef14a7687fe7edc3085c4f62022-12-21T20:01:58ZengThe Company of BiologistsDisease Models & Mechanisms1754-84111754-84032015-12-018121491149410.1242/dmm.024059024059Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi IgakiTatsushi Igaki is currently based at the Kyoto University Graduate School of Biostudies, where he leads a research group dedicated to using Drosophila genetics to build a picture of the cell-cell communications underlying the establishment and maintenance of multicellular systems. His work has provided insight into the molecular bases of cell competition in the context of development and tumorigenesis, including the landmark discovery that oncogenic cells communicate with normal cells in the tumor microenvironment to induce tumor progression in a non-autonomous fashion. In this interview, he describes his career path, highlighting the shift in his research focus from the basic principles of apoptosis to clonal evolution in cancer, and also explains why Drosophila provides a powerful model system for studying cancer biology.http://dmm.biologists.org/content/8/12/1491DrosophilaApoptosisCancer |
| spellingShingle | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki Disease Models & Mechanisms Drosophila Apoptosis Cancer |
| title | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki |
| title_full | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki |
| title_fullStr | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki |
| title_full_unstemmed | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki |
| title_short | Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki |
| title_sort | communicating the molecular basis of cancer cell by cell an interview with tatsushi igaki |
| topic | Drosophila Apoptosis Cancer |
| url | http://dmm.biologists.org/content/8/12/1491 |