Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics
This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposoma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/13/7/674 |
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| author | Luís Pereira Frederico Castelo Ferreira Filipa Pires Carla A. M. Portugal |
| author_facet | Luís Pereira Frederico Castelo Ferreira Filipa Pires Carla A. M. Portugal |
| author_sort | Luís Pereira |
| collection | DOAJ |
| description | This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine. |
| first_indexed | 2024-03-11T00:50:43Z |
| format | Article |
| id | doaj.art-44b206589cd94c78b1bc1d751844b8b0 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-11T00:50:43Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-44b206589cd94c78b1bc1d751844b8b02023-11-18T20:26:45ZengMDPI AGMembranes2077-03752023-07-0113767410.3390/membranes13070674Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release KineticsLuís Pereira0Frederico Castelo Ferreira1Filipa Pires2Carla A. M. Portugal3LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology (FCT NOVA), Universidade Nova de Lisboa, 2829-516 Caparica, PortugalDepartment of Bioengineering and iBB—Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, PortugalLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology (FCT NOVA), Universidade Nova de Lisboa, 2829-516 Caparica, PortugalLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology (FCT NOVA), Universidade Nova de Lisboa, 2829-516 Caparica, PortugalThis work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine.https://www.mdpi.com/2077-0375/13/7/674drug release kineticsmagnetic fieldliposomes |
| spellingShingle | Luís Pereira Frederico Castelo Ferreira Filipa Pires Carla A. M. Portugal Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics Membranes drug release kinetics magnetic field liposomes |
| title | Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics |
| title_full | Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics |
| title_fullStr | Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics |
| title_full_unstemmed | Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics |
| title_short | Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics |
| title_sort | magnetic responsive liposomal hydrogel membranes for controlled release of small bioactive molecules an insight into the release kinetics |
| topic | drug release kinetics magnetic field liposomes |
| url | https://www.mdpi.com/2077-0375/13/7/674 |
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