An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice
The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/2/95 |
| _version_ | 1797478539242504192 |
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| author | Lili Guo Na Guan Wenjun Miao Wenwen Zhao Qiu Li |
| author_facet | Lili Guo Na Guan Wenjun Miao Wenwen Zhao Qiu Li |
| author_sort | Lili Guo |
| collection | DOAJ |
| description | The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes. |
| first_indexed | 2024-03-09T21:33:14Z |
| format | Article |
| id | doaj.art-44b225667b46467bba3183584f91c64e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T21:33:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-44b225667b46467bba3183584f91c64e2023-11-23T20:49:44ZengMDPI AGMarine Drugs1660-33972022-01-012029510.3390/md20020095An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic MiceLili Guo0Na Guan1Wenjun Miao2Wenwen Zhao3Qiu Li4Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao 266109, ChinaAgricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao 266109, ChinaAgricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266021, ChinaAgricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao 266109, ChinaThe design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.https://www.mdpi.com/1660-3397/20/2/95enteromorpha polysaccharideanti-inflammatorydiabetic wound healing |
| spellingShingle | Lili Guo Na Guan Wenjun Miao Wenwen Zhao Qiu Li An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice Marine Drugs enteromorpha polysaccharide anti-inflammatory diabetic wound healing |
| title | An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice |
| title_full | An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice |
| title_fullStr | An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice |
| title_full_unstemmed | An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice |
| title_short | An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice |
| title_sort | electrospun scaffold loaded with an enteromorpha polysaccharide for accelerated wound healing in diabetic mice |
| topic | enteromorpha polysaccharide anti-inflammatory diabetic wound healing |
| url | https://www.mdpi.com/1660-3397/20/2/95 |
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