Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study
Vaccination can provide reliable and long-lasting protection against COVID-19, however the immune response to vaccination can vary between individuals and can decline over time, leading to differences in protective effects. Here the authors assess the immune response to COVID-19 vaccination across a...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33550-z |
| _version_ | 1828167157937078272 |
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| author | Madhumita Shrotri Ellen Fragaszy Vincent Nguyen Annalan M. D. Navaratnam Cyril Geismar Sarah Beale Jana Kovar Thomas E. Byrne Wing Lam Erica Fong Parth Patel Anna Aryee Isobel Braithwaite Anne M. Johnson Alison Rodger Andrew C. Hayward Robert W. Aldridge |
| author_facet | Madhumita Shrotri Ellen Fragaszy Vincent Nguyen Annalan M. D. Navaratnam Cyril Geismar Sarah Beale Jana Kovar Thomas E. Byrne Wing Lam Erica Fong Parth Patel Anna Aryee Isobel Braithwaite Anne M. Johnson Alison Rodger Andrew C. Hayward Robert W. Aldridge |
| author_sort | Madhumita Shrotri |
| collection | DOAJ |
| description | Vaccination can provide reliable and long-lasting protection against COVID-19, however the immune response to vaccination can vary between individuals and can decline over time, leading to differences in protective effects. Here the authors assess the immune response to COVID-19 vaccination across a large cohort of previously uninfected adults and demonstrate lower post-vaccination antibody levels amongst those with immune-suppressing conditions and medications, as well as those with several other more common chronic conditions. |
| first_indexed | 2024-04-12T02:14:27Z |
| format | Article |
| id | doaj.art-44b2456316a14f23a4cde3c70d701006 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T02:14:27Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-44b2456316a14f23a4cde3c70d7010062022-12-22T03:52:18ZengNature PortfolioNature Communications2041-17232022-10-0113111010.1038/s41467-022-33550-zSpike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort studyMadhumita Shrotri0Ellen Fragaszy1Vincent Nguyen2Annalan M. D. Navaratnam3Cyril Geismar4Sarah Beale5Jana Kovar6Thomas E. Byrne7Wing Lam Erica Fong8Parth Patel9Anna Aryee10Isobel Braithwaite11Anne M. Johnson12Alison Rodger13Andrew C. Hayward14Robert W. Aldridge15Institute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Epidemiology and Health Care, University College LondonInstitute of Epidemiology and Health Care, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute of Health Informatics, University College LondonInstitute for Global Health, University College LondonInstitute for Global Health, University College LondonInstitute of Epidemiology and Health Care, University College LondonInstitute of Health Informatics, University College LondonVaccination can provide reliable and long-lasting protection against COVID-19, however the immune response to vaccination can vary between individuals and can decline over time, leading to differences in protective effects. Here the authors assess the immune response to COVID-19 vaccination across a large cohort of previously uninfected adults and demonstrate lower post-vaccination antibody levels amongst those with immune-suppressing conditions and medications, as well as those with several other more common chronic conditions.https://doi.org/10.1038/s41467-022-33550-z |
| spellingShingle | Madhumita Shrotri Ellen Fragaszy Vincent Nguyen Annalan M. D. Navaratnam Cyril Geismar Sarah Beale Jana Kovar Thomas E. Byrne Wing Lam Erica Fong Parth Patel Anna Aryee Isobel Braithwaite Anne M. Johnson Alison Rodger Andrew C. Hayward Robert W. Aldridge Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study Nature Communications |
| title | Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study |
| title_full | Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study |
| title_fullStr | Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study |
| title_full_unstemmed | Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study |
| title_short | Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study |
| title_sort | spike antibody responses to covid 19 vaccination by demographic and clinical factors in a prospective community cohort study |
| url | https://doi.org/10.1038/s41467-022-33550-z |
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