Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient
A 23-year-old, HIV-negative woman who had undergone a hematopoietic stem cell transplantation was admitted to the hospital with respiratory failure and symptoms of bronchiolitis obliterans. A chest computed tomography scan revealed diffuse ground-glass opacification and fibrous plugs. Due to worseni...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971218344825 |
| _version_ | 1811236623847784448 |
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| author | Marta Kicia Mariola Sędzimirska Bohumil Sak Martin Kváč Maria Wesołowska Andrzej B. Hendrich Żaneta Kopacz |
| author_facet | Marta Kicia Mariola Sędzimirska Bohumil Sak Martin Kváč Maria Wesołowska Andrzej B. Hendrich Żaneta Kopacz |
| author_sort | Marta Kicia |
| collection | DOAJ |
| description | A 23-year-old, HIV-negative woman who had undergone a hematopoietic stem cell transplantation was admitted to the hospital with respiratory failure and symptoms of bronchiolitis obliterans. A chest computed tomography scan revealed diffuse ground-glass opacification and fibrous plugs. Due to worsening respiratory failure despite treatment, ventilation was provided through a tracheostomy tube. Molecular examination of bronchoalveolar lavage and urine revealed Enterocytozoon bieneusi infection. After treatment with albendazole the patient gradually improved, but the pathogen was not eradicated and reappeared on follow-up examination. E. bieneusi belongs to the most clinically important microsporidial species infecting humans, mostly those who are immunocompromised. This fungus tends to infect enterocytes of the intestine, and there are limited studies concerning its extraintestinal location. This is the first report of a case of disseminated respiratory and urinary E. bieneusi infection in a transplant recipient. Keywords: Enterocytozoon bieneusi, Respiratory tract infection, Hematopoietic stem cell transplant |
| first_indexed | 2024-04-12T12:12:16Z |
| format | Article |
| id | doaj.art-44b47734db6f4d5eaa54e5247196a171 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-12T12:12:16Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-44b47734db6f4d5eaa54e5247196a1712022-12-22T03:33:33ZengElsevierInternational Journal of Infectious Diseases1201-97122018-12-01772628Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipientMarta Kicia0Mariola Sędzimirska1Bohumil Sak2Martin Kváč3Maria Wesołowska4Andrzej B. Hendrich5Żaneta Kopacz6Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland; Corresponding author at: Department of Biology and Medical Parasitology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 9, 50-367 Wroclaw, Poland.Lower Silesian Center for Cellular Transplantations, Wroclaw, PolandBiology Centre of the Czech Academy of Sciences, Institute of Parasitology, České Budějovice, Czech RepublicBiology Centre of the Czech Academy of Sciences, Institute of Parasitology, České Budějovice, Czech Republic; University of South Bohemia, Faculty of Agriculture, České Budějovice, Czech RepublicDepartment of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, PolandDepartment of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, PolandDepartment of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, PolandA 23-year-old, HIV-negative woman who had undergone a hematopoietic stem cell transplantation was admitted to the hospital with respiratory failure and symptoms of bronchiolitis obliterans. A chest computed tomography scan revealed diffuse ground-glass opacification and fibrous plugs. Due to worsening respiratory failure despite treatment, ventilation was provided through a tracheostomy tube. Molecular examination of bronchoalveolar lavage and urine revealed Enterocytozoon bieneusi infection. After treatment with albendazole the patient gradually improved, but the pathogen was not eradicated and reappeared on follow-up examination. E. bieneusi belongs to the most clinically important microsporidial species infecting humans, mostly those who are immunocompromised. This fungus tends to infect enterocytes of the intestine, and there are limited studies concerning its extraintestinal location. This is the first report of a case of disseminated respiratory and urinary E. bieneusi infection in a transplant recipient. Keywords: Enterocytozoon bieneusi, Respiratory tract infection, Hematopoietic stem cell transplanthttp://www.sciencedirect.com/science/article/pii/S1201971218344825 |
| spellingShingle | Marta Kicia Mariola Sędzimirska Bohumil Sak Martin Kváč Maria Wesołowska Andrzej B. Hendrich Żaneta Kopacz Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient International Journal of Infectious Diseases |
| title | Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient |
| title_full | Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient |
| title_fullStr | Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient |
| title_full_unstemmed | Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient |
| title_short | Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient |
| title_sort | respiratory microsporidiosis caused by enterocytozoon bieneusi in an hiv negative hematopoietic stem cell transplant recipient |
| url | http://www.sciencedirect.com/science/article/pii/S1201971218344825 |
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