Roles of Toll-Like Receptor 3 in Human Tumors
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.667454/full |
| _version_ | 1830190348566003712 |
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| author | Xin Zheng Song Li Hui Yang |
| author_facet | Xin Zheng Song Li Hui Yang |
| author_sort | Xin Zheng |
| collection | DOAJ |
| description | Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3 has also been detected in some tumors. However TLR3 can play protumor or antitumor roles in different tumors or cell lines. Here, we review the basic signaling associated with TLR3 and the pro- or antitumor roles of TLR3 in different types of tumors and discuss the possible reasons for the opposing roles of TLR3 in tumors. |
| first_indexed | 2024-12-17T23:20:20Z |
| format | Article |
| id | doaj.art-44b56712193a445f9acf3aa0981f40e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T23:20:20Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-44b56712193a445f9acf3aa0981f40e62022-12-21T21:28:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.667454667454Roles of Toll-Like Receptor 3 in Human TumorsXin ZhengSong LiHui YangToll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3 has also been detected in some tumors. However TLR3 can play protumor or antitumor roles in different tumors or cell lines. Here, we review the basic signaling associated with TLR3 and the pro- or antitumor roles of TLR3 in different types of tumors and discuss the possible reasons for the opposing roles of TLR3 in tumors.https://www.frontiersin.org/articles/10.3389/fimmu.2021.667454/fullToll-like receptor 3 - TLR-3tumorsopposing roledsRNApathogen-associated molecular pattern |
| spellingShingle | Xin Zheng Song Li Hui Yang Roles of Toll-Like Receptor 3 in Human Tumors Frontiers in Immunology Toll-like receptor 3 - TLR-3 tumors opposing role dsRNA pathogen-associated molecular pattern |
| title | Roles of Toll-Like Receptor 3 in Human Tumors |
| title_full | Roles of Toll-Like Receptor 3 in Human Tumors |
| title_fullStr | Roles of Toll-Like Receptor 3 in Human Tumors |
| title_full_unstemmed | Roles of Toll-Like Receptor 3 in Human Tumors |
| title_short | Roles of Toll-Like Receptor 3 in Human Tumors |
| title_sort | roles of toll like receptor 3 in human tumors |
| topic | Toll-like receptor 3 - TLR-3 tumors opposing role dsRNA pathogen-associated molecular pattern |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.667454/full |
| work_keys_str_mv | AT xinzheng rolesoftolllikereceptor3inhumantumors AT songli rolesoftolllikereceptor3inhumantumors AT huiyang rolesoftolllikereceptor3inhumantumors |