Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
CONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters. AIMS: This study aimed to compare PIs in patients with d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2023;volume=17;issue=1;spage=21;epage=27;aulast=Asha |
| _version_ | 1797866767230435328 |
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| author | J Asha Nithya M Baiju Susheela J Innah Aboobacker Rafi Bins M John |
| author_facet | J Asha Nithya M Baiju Susheela J Innah Aboobacker Rafi Bins M John |
| author_sort | J Asha |
| collection | DOAJ |
| description | CONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.
AIMS: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.
SETTINGS AND DESIGN: Prospective observational study in a tertiary care center, Thrissur, Kerala.
SUBJECTS AND METHODS: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.
STATISTICAL ANALYSIS USED: Independent t-test, Chi-square test, Karl Pearson correlation coefficient.
RESULTS: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.
CONCLUSIONS: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue. |
| first_indexed | 2024-04-09T23:29:33Z |
| format | Article |
| id | doaj.art-44b58eefed5f4323a96baa94929529ff |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-09T23:29:33Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-44b58eefed5f4323a96baa94929529ff2023-03-21T07:27:37ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652023-01-01171212710.4103/ajts.AJTS_24_20Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care centerJ AshaNithya M BaijuSusheela J InnahAboobacker RafiBins M JohnCONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters. AIMS: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements. SETTINGS AND DESIGN: Prospective observational study in a tertiary care center, Thrissur, Kerala. SUBJECTS AND METHODS: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected. STATISTICAL ANALYSIS USED: Independent t-test, Chi-square test, Karl Pearson correlation coefficient. RESULTS: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion. CONCLUSIONS: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.http://www.ajts.org/article.asp?issn=0973-6247;year=2023;volume=17;issue=1;spage=21;epage=27;aulast=Ashadengueimmature platelet fractionmean platelet volumeplatelet countplatelet distribution widthplatelet large cell ratioplatelet transfusionplateletcrit |
| spellingShingle | J Asha Nithya M Baiju Susheela J Innah Aboobacker Rafi Bins M John Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center Asian Journal of Transfusion Science dengue immature platelet fraction mean platelet volume platelet count platelet distribution width platelet large cell ratio platelet transfusion plateletcrit |
| title | Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center |
| title_full | Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center |
| title_fullStr | Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center |
| title_full_unstemmed | Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center |
| title_short | Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center |
| title_sort | comparison of platelet indices in dengue fever patients based on platelet transfusion a prospective observational study in a tertiary care center |
| topic | dengue immature platelet fraction mean platelet volume platelet count platelet distribution width platelet large cell ratio platelet transfusion plateletcrit |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2023;volume=17;issue=1;spage=21;epage=27;aulast=Asha |
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