Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far
Cancers are known to have multifactorial etiology. Certain bacteria and viruses are proven carcinogens. Lately, there has been in-depth research investigating carcinogenic capabilities of some bacteria. Reports indicate that chronic inflammation and harmful bacterial metabolites to be strong promote...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.836004/full |
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| author | Shashanka K. Prasad Smitha Bhat Dharini Shashank Akshatha C. R. Sindhu R. Pornchai Rachtanapun Pornchai Rachtanapun Devananda Devegowda Prasanna K. Santhekadur Sarana Rose Sommano Sarana Rose Sommano |
| author_facet | Shashanka K. Prasad Smitha Bhat Dharini Shashank Akshatha C. R. Sindhu R. Pornchai Rachtanapun Pornchai Rachtanapun Devananda Devegowda Prasanna K. Santhekadur Sarana Rose Sommano Sarana Rose Sommano |
| author_sort | Shashanka K. Prasad |
| collection | DOAJ |
| description | Cancers are known to have multifactorial etiology. Certain bacteria and viruses are proven carcinogens. Lately, there has been in-depth research investigating carcinogenic capabilities of some bacteria. Reports indicate that chronic inflammation and harmful bacterial metabolites to be strong promoters of neoplasticity. Helicobacter pylori-induced gastric adenocarcinoma is the best illustration of the chronic inflammation paradigm of oncogenesis. Chronic inflammation, which produces excessive reactive oxygen species (ROS) is hypothesized to cause cancerous cell proliferation. Other possible bacteria-dependent mechanisms and virulence factors have also been suspected of playing a vital role in the bacteria-induced-cancer(s). Numerous attempts have been made to explore and establish the possible relationship between the two. With the growing concerns on anti-microbial resistance and over-dependence of mankind on antibiotics to treat bacterial infections, it must be deemed critical to understand and identify carcinogenic bacteria, to establish their role in causing cancer. |
| first_indexed | 2024-12-21T04:44:22Z |
| format | Article |
| id | doaj.art-44b74c5703da42668df0b86033c30be3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T04:44:22Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-44b74c5703da42668df0b86033c30be32022-12-21T19:15:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.836004836004Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So FarShashanka K. Prasad0Smitha Bhat1Dharini Shashank2Akshatha C. R.3Sindhu R.4Pornchai Rachtanapun5Pornchai Rachtanapun6Devananda Devegowda7Prasanna K. Santhekadur8Sarana Rose Sommano9Sarana Rose Sommano10Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, Jagadguru Sri Shivarathreeshwara (JSS) Academy of Higher Education and Research (JSSAHER), Mysuru, IndiaDepartment of Biotechnology and Bioinformatics, Faculty of Life Sciences, Jagadguru Sri Shivarathreeshwara (JSS) Academy of Higher Education and Research (JSSAHER), Mysuru, IndiaDepartment of General Surgery, Adichunchanagiri Institute of Medical Sciences, Mandya, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Microbiology, Faculty of Life Sciences, Jagadguru Sri Shivarathreeshwara (JSS) Academy of Higher Education and Research (JSSAHER), Mysuru, IndiaSchool of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai, ThailandCluster of Agro Bio-Circular-Green Industry (Agro BCG), Chiang Mai University, Chiang Mai, ThailandCentre of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research (JSSAHER), Mysuru, IndiaCentre of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research (JSSAHER), Mysuru, IndiaCluster of Agro Bio-Circular-Green Industry (Agro BCG), Chiang Mai University, Chiang Mai, ThailandDepartment of Plant and Soil Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai, ThailandCancers are known to have multifactorial etiology. Certain bacteria and viruses are proven carcinogens. Lately, there has been in-depth research investigating carcinogenic capabilities of some bacteria. Reports indicate that chronic inflammation and harmful bacterial metabolites to be strong promoters of neoplasticity. Helicobacter pylori-induced gastric adenocarcinoma is the best illustration of the chronic inflammation paradigm of oncogenesis. Chronic inflammation, which produces excessive reactive oxygen species (ROS) is hypothesized to cause cancerous cell proliferation. Other possible bacteria-dependent mechanisms and virulence factors have also been suspected of playing a vital role in the bacteria-induced-cancer(s). Numerous attempts have been made to explore and establish the possible relationship between the two. With the growing concerns on anti-microbial resistance and over-dependence of mankind on antibiotics to treat bacterial infections, it must be deemed critical to understand and identify carcinogenic bacteria, to establish their role in causing cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.836004/fulloncogenesischronic inflammationHelicobacter pyloribacteriacarcinogen |
| spellingShingle | Shashanka K. Prasad Smitha Bhat Dharini Shashank Akshatha C. R. Sindhu R. Pornchai Rachtanapun Pornchai Rachtanapun Devananda Devegowda Prasanna K. Santhekadur Sarana Rose Sommano Sarana Rose Sommano Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far Frontiers in Oncology oncogenesis chronic inflammation Helicobacter pylori bacteria carcinogen |
| title | Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far |
| title_full | Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far |
| title_fullStr | Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far |
| title_full_unstemmed | Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far |
| title_short | Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far |
| title_sort | bacteria mediated oncogenesis and the underlying molecular intricacies what we know so far |
| topic | oncogenesis chronic inflammation Helicobacter pylori bacteria carcinogen |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.836004/full |
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