Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases
Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well esta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3636 |
| _version_ | 1797439058802114560 |
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| author | Agata Buonacera Benedetta Stancanelli Michele Colaci Lorenzo Malatino |
| author_facet | Agata Buonacera Benedetta Stancanelli Michele Colaci Lorenzo Malatino |
| author_sort | Agata Buonacera |
| collection | DOAJ |
| description | Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity. |
| first_indexed | 2024-03-09T11:47:21Z |
| format | Article |
| id | doaj.art-44b8370a055f42bbabbbb43983eb5405 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:47:21Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-44b8370a055f42bbabbbb43983eb54052023-11-30T23:19:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237363610.3390/ijms23073636Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and DiseasesAgata Buonacera0Benedetta Stancanelli1Michele Colaci2Lorenzo Malatino3Emergency Department, Policlinico S. Marco, 95121 Catania, ItalyUnit of Internal Medicine, Policlinico S. Marco, 95121 Catania, ItalyAcademic Unit of Internal Medicine and Hypertension Centre, Department of Clinical and Experimental Medicine, University of Catania, Cannizzaro Hospital, 95126 Catania, ItalyAcademic Unit of Internal Medicine and Hypertension Centre, Department of Clinical and Experimental Medicine, University of Catania, Cannizzaro Hospital, 95126 Catania, ItalyOver the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity.https://www.mdpi.com/1422-0067/23/7/3636neutrophil-to-lymphocyte ratio (NLR)markerprognosismortalitysepsisintensive care unit (ICU) |
| spellingShingle | Agata Buonacera Benedetta Stancanelli Michele Colaci Lorenzo Malatino Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases International Journal of Molecular Sciences neutrophil-to-lymphocyte ratio (NLR) marker prognosis mortality sepsis intensive care unit (ICU) |
| title | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
| title_full | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
| title_fullStr | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
| title_full_unstemmed | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
| title_short | Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases |
| title_sort | neutrophil to lymphocyte ratio an emerging marker of the relationships between the immune system and diseases |
| topic | neutrophil-to-lymphocyte ratio (NLR) marker prognosis mortality sepsis intensive care unit (ICU) |
| url | https://www.mdpi.com/1422-0067/23/7/3636 |
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