Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype
Endometrial cancer (EC) is one of the three most prevalent gynecological tumors affecting women and is the most prevalent gynecological malignancy in the developed world. Its incidence is rapidly increasing worldwide, mostly affecting postmenopausal women, whereas recently its prevalence has increas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1278863/full |
| _version_ | 1827788694942121984 |
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| author | Chong Zhang Ming Wang Yumei Wu |
| author_facet | Chong Zhang Ming Wang Yumei Wu |
| author_sort | Chong Zhang |
| collection | DOAJ |
| description | Endometrial cancer (EC) is one of the three most prevalent gynecological tumors affecting women and is the most prevalent gynecological malignancy in the developed world. Its incidence is rapidly increasing worldwide, mostly affecting postmenopausal women, whereas recently its prevalence has increased in younger people. EC is an immune gene disease and many studies have shown that the tumor-immunosuppressive microenvironment plays an important role in cancer progression. In recent years, findings regarding the immunosuppressive tumor microenvironment (ITME) of EC have included immune evasion mechanisms and immunotherapy, which are mostly immune checkpoint inhibitors (ICI) for EC. Recently studies on the ITME of different molecular types of EC have found that different molecular types may have different ITME. With the research on the immune microenvironment of EC, a new immunophenotype classification based on the immune microenvironment has been carried out in recent years. However, the impact of the ITME on EC remains unclear, and the immunophenotype of EC remains limited to the research stage. Our review describes recent findings regarding the ITME features of different EC molecular types. The advent of immunotherapy has brought hope for improved efficacy and prognosis in patients with advanced or recurrent EC. The efficacy and safety of ICIs combination therapy remains the focus of future research. |
| first_indexed | 2024-03-11T17:09:10Z |
| format | Article |
| id | doaj.art-44b90e83f23549c8a4600b0bcdea2a2d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T17:09:10Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-44b90e83f23549c8a4600b0bcdea2a2d2023-10-20T06:38:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12788631278863Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtypeChong Zhang0Ming Wang1Yumei Wu2Departments of Obstetrics, Beijing You’an Hospital of Capital Medical University, Beijing, ChinaDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaEndometrial cancer (EC) is one of the three most prevalent gynecological tumors affecting women and is the most prevalent gynecological malignancy in the developed world. Its incidence is rapidly increasing worldwide, mostly affecting postmenopausal women, whereas recently its prevalence has increased in younger people. EC is an immune gene disease and many studies have shown that the tumor-immunosuppressive microenvironment plays an important role in cancer progression. In recent years, findings regarding the immunosuppressive tumor microenvironment (ITME) of EC have included immune evasion mechanisms and immunotherapy, which are mostly immune checkpoint inhibitors (ICI) for EC. Recently studies on the ITME of different molecular types of EC have found that different molecular types may have different ITME. With the research on the immune microenvironment of EC, a new immunophenotype classification based on the immune microenvironment has been carried out in recent years. However, the impact of the ITME on EC remains unclear, and the immunophenotype of EC remains limited to the research stage. Our review describes recent findings regarding the ITME features of different EC molecular types. The advent of immunotherapy has brought hope for improved efficacy and prognosis in patients with advanced or recurrent EC. The efficacy and safety of ICIs combination therapy remains the focus of future research.https://www.frontiersin.org/articles/10.3389/fonc.2023.1278863/fullendometrial cancerimmunosuppressive tumor microenvironmentimmunophenotypemolecular subtypesimmunotherapy |
| spellingShingle | Chong Zhang Ming Wang Yumei Wu Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype Frontiers in Oncology endometrial cancer immunosuppressive tumor microenvironment immunophenotype molecular subtypes immunotherapy |
| title | Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| title_full | Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| title_fullStr | Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| title_full_unstemmed | Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| title_short | Features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| title_sort | features of the immunosuppressive tumor microenvironment in endometrial cancer based on molecular subtype |
| topic | endometrial cancer immunosuppressive tumor microenvironment immunophenotype molecular subtypes immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1278863/full |
| work_keys_str_mv | AT chongzhang featuresoftheimmunosuppressivetumormicroenvironmentinendometrialcancerbasedonmolecularsubtype AT mingwang featuresoftheimmunosuppressivetumormicroenvironmentinendometrialcancerbasedonmolecularsubtype AT yumeiwu featuresoftheimmunosuppressivetumormicroenvironmentinendometrialcancerbasedonmolecularsubtype |