SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome
Since no definitive cure for COVID-19 is available so far, one of the challenges against the disease is understanding the clinical features and the laboratory inflammatory markers that can differentiate among different severity grades of the disease. The aim of the present study is a comprehensive a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/6/826 |
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| author | Emanuela Galliera Luca Massaccesi Lina Yu Jianwen He Marco Ranucci Massimiliano M. Corsi Romanelli |
| author_facet | Emanuela Galliera Luca Massaccesi Lina Yu Jianwen He Marco Ranucci Massimiliano M. Corsi Romanelli |
| author_sort | Emanuela Galliera |
| collection | DOAJ |
| description | Since no definitive cure for COVID-19 is available so far, one of the challenges against the disease is understanding the clinical features and the laboratory inflammatory markers that can differentiate among different severity grades of the disease. The aim of the present study is a comprehensive and longitudinal evaluation of SCD14-ST and other new inflammatory markers, as well as cytokine storm molecules and current inflammatory parameters, in order to define a panel of biomarkers that could be useful for a better prognostic prediction of COVID-19 mortality. SCD14-ST, as well as the inflammatory markers IL-6, IL-10, SuPAR and sRAGE, were measured in plasma-EDTA of ICU COVID-19 positive patients. In this longitudinal study, SCD14-ST resulted significantly higher in patients who eventually died compared to those who were discharged from the ICU. The results suggest that the new infection biomarker SCD14-ST, in addition to new generation inflammatory biomarkers, such as SuPAR, sRAGE and the cytokines IL-6 and IL-10, can be a useful prognostic tool associated with canonical inflammatory parameters, such as CRP, to predict SARS-CoV-2 outcome in ICU patients. |
| first_indexed | 2024-03-10T00:17:47Z |
| format | Article |
| id | doaj.art-44b91c8ad2df4be581e6eca668c6cff4 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:17:47Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-44b91c8ad2df4be581e6eca668c6cff42023-11-23T15:47:37ZengMDPI AGBiomolecules2218-273X2022-06-0112682610.3390/biom12060826SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 OutcomeEmanuela Galliera0Luca Massaccesi1Lina Yu2Jianwen He3Marco Ranucci4Massimiliano M. Corsi Romanelli5Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyR&D Department, Mindray Bio-Medical Electronics Co., Ltd., Shenzhen 518057, ChinaR&D Department, Mindray Bio-Medical Electronics Co., Ltd., Shenzhen 518057, ChinaDepartment of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, 20097 Milan, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalySince no definitive cure for COVID-19 is available so far, one of the challenges against the disease is understanding the clinical features and the laboratory inflammatory markers that can differentiate among different severity grades of the disease. The aim of the present study is a comprehensive and longitudinal evaluation of SCD14-ST and other new inflammatory markers, as well as cytokine storm molecules and current inflammatory parameters, in order to define a panel of biomarkers that could be useful for a better prognostic prediction of COVID-19 mortality. SCD14-ST, as well as the inflammatory markers IL-6, IL-10, SuPAR and sRAGE, were measured in plasma-EDTA of ICU COVID-19 positive patients. In this longitudinal study, SCD14-ST resulted significantly higher in patients who eventually died compared to those who were discharged from the ICU. The results suggest that the new infection biomarker SCD14-ST, in addition to new generation inflammatory biomarkers, such as SuPAR, sRAGE and the cytokines IL-6 and IL-10, can be a useful prognostic tool associated with canonical inflammatory parameters, such as CRP, to predict SARS-CoV-2 outcome in ICU patients.https://www.mdpi.com/2218-273X/12/6/826SCD14-STSARS-CoV-2prediction of diseaseimmune biomarkers |
| spellingShingle | Emanuela Galliera Luca Massaccesi Lina Yu Jianwen He Marco Ranucci Massimiliano M. Corsi Romanelli SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome Biomolecules SCD14-ST SARS-CoV-2 prediction of disease immune biomarkers |
| title | SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome |
| title_full | SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome |
| title_fullStr | SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome |
| title_full_unstemmed | SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome |
| title_short | SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome |
| title_sort | scd14 st and new generation inflammatory biomarkers in the prediction of covid 19 outcome |
| topic | SCD14-ST SARS-CoV-2 prediction of disease immune biomarkers |
| url | https://www.mdpi.com/2218-273X/12/6/826 |
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