Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method
A sensitive and selective RP-HPLC method was developed and validated for the quantitative determination of trimazolin hydrochloride in nasal drops formulations. The mobile phase composition was water-acetonitrile (50:50, v/v) and the UV detection was carried out at 270 nm. Linearity range in the con...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Association of Chemical Engineers of Serbia
2009-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2009/0367-598X0902087S.pdf |
| _version_ | 1818386615422156800 |
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| author | Savić Ivana M. Nikolić Goran S. Banković Vladimir M. Savić Ivan M. |
| author_facet | Savić Ivana M. Nikolić Goran S. Banković Vladimir M. Savić Ivan M. |
| author_sort | Savić Ivana M. |
| collection | DOAJ |
| description | A sensitive and selective RP-HPLC method was developed and validated for the quantitative determination of trimazolin hydrochloride in nasal drops formulations. The mobile phase composition was water-acetonitrile (50:50, v/v) and the UV detection was carried out at 270 nm. Linearity range in the concentration range of 10 to 110 μg cm-3. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantization limits were found to be 1.45 and 4.8 μg cm-3, respectively. The results demonstrated that the procedure for estimation of trimazolin hydrochloride in nasal drops formulations was accurate, precise and reproducible. |
| first_indexed | 2024-12-14T03:56:52Z |
| format | Article |
| id | doaj.art-44bcee70cf0a44a1829aef658d58d2f8 |
| institution | Directory Open Access Journal |
| issn | 0367-598X |
| language | English |
| last_indexed | 2024-12-14T03:56:52Z |
| publishDate | 2009-01-01 |
| publisher | Association of Chemical Engineers of Serbia |
| record_format | Article |
| series | Hemijska Industrija |
| spelling | doaj.art-44bcee70cf0a44a1829aef658d58d2f82022-12-21T23:18:04ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija0367-598X2009-01-01632879310.2298/HEMIND0902087SQuantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC methodSavić Ivana M.Nikolić Goran S.Banković Vladimir M.Savić Ivan M.A sensitive and selective RP-HPLC method was developed and validated for the quantitative determination of trimazolin hydrochloride in nasal drops formulations. The mobile phase composition was water-acetonitrile (50:50, v/v) and the UV detection was carried out at 270 nm. Linearity range in the concentration range of 10 to 110 μg cm-3. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantization limits were found to be 1.45 and 4.8 μg cm-3, respectively. The results demonstrated that the procedure for estimation of trimazolin hydrochloride in nasal drops formulations was accurate, precise and reproducible.http://www.doiserbia.nb.rs/img/doi/0367-598X/2009/0367-598X0902087S.pdfTrimazolin hydrochlorideHPLCValidation |
| spellingShingle | Savić Ivana M. Nikolić Goran S. Banković Vladimir M. Savić Ivan M. Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method Hemijska Industrija Trimazolin hydrochloride HPLC Validation |
| title | Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method |
| title_full | Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method |
| title_fullStr | Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method |
| title_full_unstemmed | Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method |
| title_short | Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method |
| title_sort | quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by rp hplc method |
| topic | Trimazolin hydrochloride HPLC Validation |
| url | http://www.doiserbia.nb.rs/img/doi/0367-598X/2009/0367-598X0902087S.pdf |
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