Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

Background & Aims: Non-absorbable inhibitors of the apical sodium-dependent bile acid transporter (ASBT; also called ileal bile acid transporter [IBAT]) are recently approved or in clinical development for multiple cholestatic liver disorders and lead to a reduction in pruritus and (markers...

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Main Authors: Roni F. Kunst, Dirk R. de Waart, Frank Wolters, Suzanne Duijst, Esther W. Vogels, Isabelle Bolt, Joanne Verheij, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:JHEP Reports
Subjects:
Apical sodium-dependent bile acid transporter (ASBT)
IBAT
NTCP
BSEP
PFIC
Alagille
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922001458

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