Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis

Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis

Abstract Imine reductases (IREDs) are NADPH‐dependent enzymes (NADPH=nicotinamide adenine dinucleotide phosphate) that catalyze the reduction of imines to amines. They exhibit high enantioselectivity for a broad range of substrates, making them of interest for biocatalytic applications. In this work...

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Bibliographic Details
Main Authors: Dr. Mario Prejanò, Prof. Dr. Xiang Sheng, Prof. Dr. Fahmi Himo
Format: Article
Language:English
Published: Wiley-VCH 2022-01-01
Series:ChemistryOpen
Subjects:
biocatalysis
enantioselectivity
imine reductase
reaction mechanism
transition state
Online Access:https://doi.org/10.1002/open.202100250

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